Downregulation of AQP1, -2, and -3 after ureteral obstruction is associated with a long-term urine-concentrating defect

Previously, we demonstrated that 24 h of bilateral ureteral obstruction (BUO) and short-term release of BUO was associated with a decrease in the expression of aquaporin-2 (AQP2), polyuria, and a reduced urinary concentrating capacity (10). The purposes of the present study were to examine whether B...

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Published in:American journal of physiology. Renal physiology 2001-07, Vol.50 (1), p.F163-F171
Main Authors: CHUNLING LI, WEIDONG WANG, FRØKLAER, Jørgen, KWON, Tae-Hwan, ISIKAY, Levent, JIAN GUO WEN, MARPLES, David, DJURHUUS, Jens Christian, STOCKWELL, Anette, KNEPPER, Mark A, NIELSEN, Søren
Format: Article
Language:English
Subjects:
Biological and medical sciences
Diabetes
Excretory system
Kidneys
Medical sciences
Nephrology. Urinary tract diseases
Urinary system involvement in other diseases. Miscellaneous
Urinary tract. Prostate gland
Urology
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Summary:Previously, we demonstrated that 24 h of bilateral ureteral obstruction (BUO) and short-term release of BUO was associated with a decrease in the expression of aquaporin-2 (AQP2), polyuria, and a reduced urinary concentrating capacity (10). The purposes of the present study were to examine whether BUO and the long-term release of BUO (BUO-R) for 3, 14, and 30 days were associated with changes in the expression of renal AQP1, AQP2, and AQP3 and whether such changes were associated with parallel changes in urinary output and urinary concentrating capacity.
ISSN:1931-857X
1522-1466