Biomarkers of folate and related B-vitamins as predictors of cognitive decline in older Irish adults over a 5 year follow up period

Biomarkers of folate and related B-vitamins as predictors of cognitive decline in older Irish adults over a 5 year follow up period

The rate of cognitive decline was evaluated by re-assessment of cognition using the original battery of tests including the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), the Mini-Mental State Examination (MMSE) and the Frontal Assessment Battery (FAB). B-vitamin Biomark...

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Bibliographic Details
Published in:Proceedings of the Nutrition Society 2017, Vol.76 (OCE1), Article E4
Main Authors: Porter, K., Hughes, C.F., Hoey, L., Ward, M., Moore, K., Strain, J.J., Molloy, A., Cunningham, C., Casey, M.C., Laird, E., McCarroll, K., Pentieva, K., McNulty, H.
Format: Article
Language:eng
Subjects:
Abbreviations
Aging
Biomarkers
Cognition
Cognition & reasoning
Cognitive ability
Confidence intervals
Erythrocytes
Folic acid
Glutathione
Glutathione reductase
Homocysteine
Investigations
Red blood cells
Reductases
Riboflavin
Statistical analysis
Vitamin B
Vitamins
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Summary:The rate of cognitive decline was evaluated by re-assessment of cognition using the original battery of tests including the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), the Mini-Mental State Examination (MMSE) and the Frontal Assessment Battery (FAB). B-vitamin Biomarker status 1 Accelerated cognitive decline RBANS OR 95 % CI p value Plasma Homocysteine (μmol/L) Reference 868 vs lower status (185–865) 1·126 0·759–1·670 0·556 Serum Total B12 (pmol/L) Reference > 252 vs lower status (58–251) 0·828 0·564–1·215 0·334 Plasma PLP (B6) (nmol/L) Reference > 61·3 vs lower status (11·6–61·3) 1·537 1·039–2·273 0·032 EGRac (B2)* Reference < 1·30 vs lower status (1·30–2·03) 1·493 1·013–2·201 0·043 Binary logistic regression was performed with adjustment for age (years) and education (years). Abbreviations: OR, odds ratio; CI, confidence interval; RBC, Red Blood Cell; PLP, Plasma Pyridoxal Phosphate; *EGRac, Erythrocyte Glutathione Reductase Activation Coefficient- higher EGRac ratio indicates lower riboflavin status. 1 For each biomarker, participants with lower status were identified using the median value as the cut off point.
ISSN:0029-6651
1475-2719