B-Vitamins, blood pressure and endothelial compliance in healthy adults stratified by MTHFR genotype

B-Vitamins, blood pressure and endothelial compliance in healthy adults stratified by MTHFR genotype

Individuals homozygous for the MTHFR 677TT genotype have reduced MTHFR enzyme activity resulting in lower 5 methyl-THF concentrations(2), however previous randomised controlled trials at our Centre have shown that blood pressure (BP) is highly responsive to riboflavin supplementation specifically in...

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Bibliographic Details
Published in:Proceedings of the Nutrition Society 2018, Vol.77 (OCE3), Article E61
Main Authors: Rooney, M., Clements, M., Hughes, C.F., McNulty, H., Strain, J.J., Ward, M.
Format: Article
Language:eng
Subjects:
Blood pressure
Enzymatic activity
Enzyme activity
Enzymes
Genotype & phenotype
Genotypes
Health care
Hypertension
Methylenetetrahydrofolate reductase
Riboflavin
Supplementation
Vitamin B
Vitamins
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Summary:Individuals homozygous for the MTHFR 677TT genotype have reduced MTHFR enzyme activity resulting in lower 5 methyl-THF concentrations(2), however previous randomised controlled trials at our Centre have shown that blood pressure (BP) is highly responsive to riboflavin supplementation specifically in individuals with the TT genotype(3). Preliminary results in a subset of the study cohort, summarised in the table above, show that systolic BP is markedly higher in participants with the TT genotype, compared to CC and CT genotypes, with a similar, albeit non-significant, trend for diastolic BP. [...]this study has shown for the first time that individuals with the MTHFR TT genotype have poorer endothelial function compared to their age-matched CC genotype counterparts.
ISSN:0029-6651
1475-2719