A randomised controlled trial of B-vitamin supplementation on neuropsychiatric performance: results from the BrainHOP trial

A randomised controlled trial of B-vitamin supplementation on neuropsychiatric performance: results from the BrainHOP trial

Globally populations are ageing and mental health disorders, including dementia and depression, are reported as the leading cause of disability and ill health in older people(1). Placebo (n 125) B-vitamin (n 124) Mean SD Mean SD P* Age (at baseline) 78·2 4·7 77·9 4·2 0·607 Gender (male) n % 80 48·5...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the Nutrition Society 2018, Vol.77 (OCE3), Article E73
Main Authors: Moore, K., Porter, K., Doherty, L.C., Hughes, C.F., Ward, M., Hoey, L., Strain, J.J., Pentieva, K., McNulty, H.
Format: Article
Language:eng
Subjects:
Aging
Anxiety
Cognition
Cognition & reasoning
Cognitive ability
Dementia disorders
Hyperlipidemia
Hypertension
Intervention
Mental depression
Mental disorders
Mental health
Older people
Smoking
Supplementation
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Globally populations are ageing and mental health disorders, including dementia and depression, are reported as the leading cause of disability and ill health in older people(1). Placebo (n 125) B-vitamin (n 124) Mean SD Mean SD P* Age (at baseline) 78·2 4·7 77·9 4·2 0·607 Gender (male) n % 80 48·5 67 41·1 0·218 Cognitive Scores Adjusted mean SEM Adjusted mean SEM FAB Pre-intervention 14·7 0·2 15·1 0·2 Post-intervention 14·4 0·2 14·7 0·2 0·485 RBANS Total Score Pre-intervention 93·3 1·3 93·4 1·3 Post-intervention 95·5 1·4 97·8 1·4 0·117 Index II (Visuospatial Cognition) Pre-intervention 98·8 1·6 95·0 1·7 Post-intervention 95·8 1·7 99·2 1·7 0·001 * Time × treatment interaction (repeated measures ANCOVA, comparing the effect of treatment vs placebo over time, controlling for age, education, depression, anxiety, hyperlipidaemia, hypertension and smoking status. In the case of depression, although the effect of B-vitamin intervention on depression (i.e. CES-D score) did not reach statistical significance, rates of depression (i.e. % with CES-D score > 16) doubled over the 2-year period in the placebo group (from 4·0% to 8·0%) compared with a minimal increase in the B-vitamin group (from 4·0% to 4·8%) (Data not shown).
ISSN:0029-6651
1475-2719