PKCγ in Vc and C1/C2 is Involved in Trigeminal Neuropathic Pain

The aim of the present study was to clarify the involvement of protein kinase Cγ (PKCγ) in the facial neuropathic pain following infraorbital nerve injury. We analyzed the change in PKCγ expression in the trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal cord (C1/C2) following chr...

Full description

Saved in:
Bibliographic Details
Published in:Journal of dental research 2011-06, Vol.90 (6), p.777-781
Main Authors: Nakajima, A., Tsuboi, Y., Suzuki, I., Honda, K., Shinoda, M., Kondo, M., Matsuura, S., Shibuta, K., Yasuda, M., Shimizu, N., Iwata, K.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chelerythrine
Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction
Kinases
Mechanical properties
Medical sciences
Nervous system (semeiology, syndromes)
Neuralgia
Neurology
Pain perception
Protein kinase
Protein kinase C
Spinal cord injuries
Trigeminal nerve
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of the present study was to clarify the involvement of protein kinase Cγ (PKCγ) in the facial neuropathic pain following infraorbital nerve injury. We analyzed the change in PKCγ expression in the trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal cord (C1/C2) following chronic constriction injury of the infraorbital nerve (ION-CCI). We also studied ION-CCI-mediated mechanical nocifensive behavior in rats. The mechanical head-withdrawal threshold significantly decreased 1 to 14 days after ION-CCI compared with that before ION-CCI and in sham rats. The expression of PKCγ was significantly larger in the ipsilateral Vc compared with the contralateral side in ION-CCI rats 3, 7, and 14 days after ION-CCI. Intrathecal (i.t.) administration of the PKCγ inhibitor chelerythrine prevented an increase in the PKCγ expression in the ipsilateral Vc. Moreover, i.t. administration of chelerythrine annulled ION-CCI-mediated reduction in the head-withdrawal threshold. Taken together, these findings suggest that PKCγ expression in the Vc played an important role in the mechanism of orofacial static mechanical allodynia following trigeminal nerve injury.
ISSN:0022-0345
1544-0591
DOI:10.1177/0022034511401406