Comparative Pharmacokinetics and Relative Bioavailability of a New Anxiolytic GML-1 in Tablet Form

An open, single, crossover, pharmacokinetic study of GML-1 (dose 50 mg/kg) in rabbits after its oral administration in tablets and alone as a substance is carried out. The following pharmacokinetic parameters are calculated: the maximum concentration of GML-1 in blood plasma ( C max ) of rabbits, th...

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Bibliographic Details
Published in:Moscow University chemistry bulletin 2019-07, Vol.74 (4), p.204-207
Main Authors: Novitskiy, A. A., Litvin, A. A., Shevchenko, R. V., Bochkov, P. O., Gribakina, O. G., Kolyvanov, G. B., Zherdev, V. P., Alekseev, K. V., Blynskaya, E. V., Yudina, D. V., Smirnov, V. V.
Format: Article
Language:English
Subjects:
Antiretroviral drugs
Bioavailability
Blood plasma
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Pharmacokinetics
Pharmacology
Rabbits
Tablets
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Summary:An open, single, crossover, pharmacokinetic study of GML-1 (dose 50 mg/kg) in rabbits after its oral administration in tablets and alone as a substance is carried out. The following pharmacokinetic parameters are calculated: the maximum concentration of GML-1 in blood plasma ( C max ) of rabbits, the time required to reach C max , the area under the concentration-time curve, the half-time of GML-1, and the relative bioavailability. The GML-1 concentration is detected with the use of the HPLC-MS (ion trap) by the daughter ions. The relative bioavailability of GML-1 in tablets is 101.72 ± 19.96% in comparison to the substance.
ISSN:0027-1314
1935-0260
DOI:10.3103/S0027131419040060