Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase

The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. In this study, we found that UP overexpression by gene transfer, and the subsequent efficient metabolic activation of 5-fluorouracil (5-FU) by the ribonucl...

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Bibliographic Details
Published in:British journal of cancer 2001-06, Vol.84 (12), p.1677-1680
Main Authors: CUQ, P, ROUQUET, C, EVRARD, A, CICCOLINI, J, VIAN, L, CANO, J-P
Format: Article
Language:English
Subjects:
Antimetabolites, Antineoplastic - pharmacology
Antineoplastic agents
Biological and medical sciences
Breast cancer
Breast Neoplasms - pathology
Cancer research
Cloning
Combined treatments (chemotherapy of immunotherapy associated with an other treatment)
Cytotoxicity
Female
Fluorouracil - pharmacology
Gene therapy
Genetic Therapy
Humans
Medical research
Medical sciences
Metabolism
Metabolites
Pharmacology. Drug treatments
Ribonucleotides
Transfection
Tumor Cells, Cultured
Uridine Phosphorylase - biosynthesis
Uridine Phosphorylase - genetics
Uridine Phosphorylase - metabolism
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Summary:The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. In this study, we found that UP overexpression by gene transfer, and the subsequent efficient metabolic activation of 5-fluorouracil (5-FU) by the ribonucleotide pathway, does not increase the fluoropyrimidine sensitivity of MCF-7 human cancer cells.
ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1054/bjoc.2001.1833