Preparation, Structural characterization and DNA binding/cleavage affinity of new bioactive nano‐sized metal (II/IV) complexes with oxazon‐Schiff's base ligand

A novel oxazon‐Schiff's base ligand named (E)‐3‐(2‐(4‐(diethylamino)‐2‐hydroxybenzylidene)hydrazineyl)‐2H‐benzo[b][1,4]oxazin‐2‐one (HL) has been synthesized in addition to its nano‐sized divalent and tetravalent Mn (II), Co (II), Ni (II), Cu (II), Zn (II) and Pt (IV) complexes. The structures...

Full description

Saved in:
Bibliographic Details
Published in:Applied organometallic chemistry 2019-10, Vol.33 (10), p.n/a
Main Authors: M.A. Alaghaz, Abdel‐Nasser, Aldulmani, Sharah A.A.
Format: Article
Language:English
Subjects:
anticancer
ATF
Binding
Biocompatibility
Biotechnology
Cancer
Carbonyls
Chemical analysis
Chemistry
Cleavage
Coordination compounds
Copper
Deoxyribonucleic acid
DNA
DNA binding
Electron transfer
Infrared analysis
Ligands
Magnetic moments
Manganese
Mathematical analysis
Metals
Nano‐sized metal (II/IV) complexes
Nickel
NMR
Nuclear magnetic resonance
Oxazon‐Schiff base
Platinum
Stoichiometry
Structural analysis
Synthesis
Thermal analysis
Titration
Zinc
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel oxazon‐Schiff's base ligand named (E)‐3‐(2‐(4‐(diethylamino)‐2‐hydroxybenzylidene)hydrazineyl)‐2H‐benzo[b][1,4]oxazin‐2‐one (HL) has been synthesized in addition to its nano‐sized divalent and tetravalent Mn (II), Co (II), Ni (II), Cu (II), Zn (II) and Pt (IV) complexes. The structures and geometries of the synthesized compounds have been confirmed using the different analytical and spectroscopic tools such as elemental analysis, uv–vis., IR, HR‐MS, 1H NMR, ESR, TGA, XRD, EDX, TEM, SEM, AFM, magnetic and molar conductivity measurements. The elemental analyses confirm 1 M: 2 L stoichiometry of the type [PtL2].2Cl and [ML2] (M = Mn (II), Co (II), Ni (II), Cu (II) and Zn (II)). The FT‐IR spectral studies illustrated that the ligand bind to the metal ions through the phenolic hydroxy oxygen, azo methine nitrogen carbonyl oxazin oxygen. The spectral tools; UV–Vis, ligand field parameters and ESR in addition to the magnetic moment measurements confirmed octahedral geometry around the metal centres. The absence of coordinated or hydrated water complexes were confirmed by thermal analysis data of the complexes. The electron transfer reactions for the complexes have been studied by cyclic voltammetry. XRD, SEM, TEM, and AFM images confirmed nano‐sized particles and homogeneous distribution over the complex surface. The mode of binding of the complexes with DNA has been performed through electronic absorption titration and viscosity studies. The reaction between the metal complexes and DNA were studied by DNA cleavage. In general, MCF‐7 cell were least sensitive to the tested compounds and all compounds were considerably more toxic to the studied cancer cell lines than to the normal cell line HepG‐2. The binding mode of the compounds and DNA was preferably via intercalation. In addition, these results were confirmed based on theoretical studies. Finally, a linear and exponential correlation between interaction constant (Kb) and IC50 for two human cancer cell was observed. Novel Schiff base (HL)ligand was prepared.? General formula of the synthesized complexesis [M(L)2], (M = Co(II); Ni(II), Cu(II), Zn(II) and[Pt(L)2]Cl2 homogeneous distribution over the complex surface has been confirmed nano‐sizedparticles. ?Biological activities on different bacterial, fungal, cytotoxical.
ISSN:0268-2605
1099-0739
DOI:10.1002/aoc.5135