Relaxation effect of CGP-48506, EMD-57033, and dobutamine in ejecting and isovolumically beating rabbit hearts

Because it is not known whether ejection influences the negative effect of the Ca2+ -sensitizing drugs on ventricular relaxation, we extended our previous analysis of stress dependent relaxation in isovolumic beats to encompass ejecting beats and evaluated the relationships between both the time of...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 1997-12, Vol.42 (6), p.H2708-H2720
Main Authors: SLINKER, B. K, GREEN, H. W, WU, Y, KIRKPATRICK, R. D, CAMPBELL, K. B
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Cardiovascular system
Circulatory system
Heart
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
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Summary:Because it is not known whether ejection influences the negative effect of the Ca2+ -sensitizing drugs on ventricular relaxation, we extended our previous analysis of stress dependent relaxation in isovolumic beats to encompass ejecting beats and evaluated the relationships between both the time of onset of relaxation and the rate of relaxation and wallstress in a broader analysis framework.
ISSN:0363-6135
1522-1539