A Novel Synthetic Route of Fused Tricyclic Framework Quinoline Derivatives from Readily Available Aliphatic Amino Carboxylic Acid Substrates

A Novel Synthetic Route of Fused Tricyclic Framework Quinoline Derivatives from Readily Available Aliphatic Amino Carboxylic Acid Substrates

A novel and an efficient strategy of fused tricyclic quinoline heterocycle compounds from aliphatic amino carboxylic acid substrates is disclosed. The protocol here is proceed over main reaction processes including: cyclization, protection, amidine formation, further cyclization and finally coupling...

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Bibliographic Details
Published in:Oriental journal of chemistry 2019-01, Vol.35 (2), p.611-617
Main Author: Mohammed, Shireen
Format: Article
Language:eng
Subjects:
Aliphatic compounds
Carboxylic acids
Chemical reactions
Chemistry
Chromatography
Fluorides
Phenols
Quinoline
Substrates
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Summary:A novel and an efficient strategy of fused tricyclic quinoline heterocycle compounds from aliphatic amino carboxylic acid substrates is disclosed. The protocol here is proceed over main reaction processes including: cyclization, protection, amidine formation, further cyclization and finally coupling with boronic acid substrate through Suzuki reaction. These reactions afforded the corresponding products in high yields. Furthermore, all synthesized compounds were identified by spectral data.
ISSN:0970-020X
2231-5039