DHA and AA Supplementation and Sleep in Toddlers Born Preterm: A Randomized Controlled Trial

Background: Children born preterm exhibit more sleep problems than their term counterparts from infancy to middle childhood. In addition, children born preterm are at increased risk of physical, neurological, behavioral and social-emotional delays and chronic medical conditions which may be further...

Full description

Saved in:
Bibliographic Details
Published in:Pediatrics (Evanston) 2019-08, Vol.144 (2_MeetingAbstract), p.621-621
Main Authors: Boone, Kelly M., Keim, Sarah A., Rausch, Joseph, Pelak, Grace, Li, Rui, Turner, Abigail Norris, Klebanoff, Mark
Format: Article
Language:English
Subjects:
Birth weight
Caregivers
Children
Children & youth
Corn oil
Demographics
Dietary supplements
Emotional behavior
Epidemiology
Gestation
Nocturnal
Pediatrics
Powder
Questionnaires
Randomization
Risk taking
Secondary analysis
Sleep
Sleep disorders
Symptomology
Toddlers
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Children born preterm exhibit more sleep problems than their term counterparts from infancy to middle childhood. In addition, children born preterm are at increased risk of physical, neurological, behavioral and social-emotional delays and chronic medical conditions which may be further exacerbated by poor sleep quality. Targeted sleep interventions may be beneficial to the health and development of children born preterm. Study Objectives: This secondary analysis aimed to describe sleep characteristics for and to explore effects of combined DHA+AA supplementation on parent-reported sleep in a sample of toddlers born preterm. Method: Omega Tots was a single-site, 180-day randomized, double blinded, placebo-controlled trial. Participants were 10-16 months of age (adjusted for prematurity) and born at 16), post hoc sub-group analyses based on these variables were performed. Analyses of treatment effects compared the change in sleep characteristics between the DHA+AA and placebo groups, controlling for baseline scores, using mixed effects regression. Three-way interaction terms tested for moderators of the treatment effect. Results: Eighty-eight percent (n=332) of randomized children had sleep outcome data. Children were 48% female, 14.9 months (corrected age, SD=1.8) at enrollment, born at an average of 31.1 (SD=2.7) completed weeks' gestation, and weighed 1727 (SD=552) grams at birth. Caregivers were predominately mothers (96%), 31.1 years (SD=7.3) old, and 17.4% reported depressive symptomology at baseline. Children were reported, at baseline, to sleep 12 hours (SD=1.9) per day, with approximately 10 hours (SD=1.6) comprising nocturnal sleep duration; 16% of children slept for less than 11 total hours per day. Children of caregivers who reported depressive symptomology experienced large and positive eff
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.144.2MA7.621