Cord Blood Banking for Potential Future Transplantation: Subject Review

In recent years, umbilical cord blood, which contains a large number of hematopoietic stem cells, has been used successfully for allogeneic transplantation to treat a variety of pediatric genetic, hematologic, and oncologic disorders. It is a potential alternative when autologous or allogeneic trans...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1999-07, Vol.104 (1), p.116-118
Main Authors: Oh, Weltham, Cairn, Mitchell S, Desposito, Franklin, Greene, Michael F, Mauer, Alvin M, Pearson, Howard A, Stevenson, David K, Wilford, Benjamin S
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood & organ donations
Blood banks
Blood collection and preservation
Bone marrow, stem cells transplantation. Graft versus host reaction
Ethical aspects
Fetal blood
Fetal blood transplantation
Medical ethics
Medical sciences
Pediatrics
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Transplantation
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Summary:In recent years, umbilical cord blood, which contains a large number of hematopoietic stem cells, has been used successfully for allogeneic transplantation to treat a variety of pediatric genetic, hematologic, and oncologic disorders. It is a potential alternative when autologous or allogeneic transplantation with HLA-matched marrow is unavailable for children. This advance has resulted in the establishment of not-for-profit and for-profit cord blood banking programs for autologous and allogeneic transplantation. Many issues confront institutions that wish to establish such a program. Parents also seek information from their physicians about this new modality. This document is intended to provide information to guide physicians in responding to parents' questions about cord blood banking. The document also makes recommendations about appropriate ethical and operational standards, including informed consent policies, for the institutions that operate a program.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.104.1.116