Cervical cancer and human papillomavirus among slum dwellers in India

Almost half a million new cases of cervical cancer are diagnosed each year worldwide. Human papillomavirus is recognised as one of the leading causes and is associated with 90% of cases. However, other risk factors (e.g., age of first sexual contact, number of sexual partners, multiparity, diet, gen...

Full description

Saved in:
Bibliographic Details
Published in:British journal of biomedical science 2007-01, Vol.64 (1), p.28-31
Main Authors: Rughooputh, S., Kachaliya, S., Jetly, D., Greenwell, P.
Format: Article
Language:English
Subjects:
Adult
Aged
Cells
Cervical cancer
Cervical intraepithelial neoplasia
Cervical neoplasms
Children & youth
Developing countries
Family planning
Female
Human papillomavirus
Humans
Immunization
India - epidemiology
LDCs
Papillomaviridae
Papillomavirus Infections - complications
Papillomavirus Infections - epidemiology
Parity
Poverty
Reproductive History
Risk Factors
Studies
Urban Health
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - virology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Almost half a million new cases of cervical cancer are diagnosed each year worldwide. Human papillomavirus is recognised as one of the leading causes and is associated with 90% of cases. However, other risk factors (e.g., age of first sexual contact, number of sexual partners, multiparity, diet, genetic predisposition and environment) are also associated with cervical cancer. The present retrospective study is performed on a cohort of women from the slums of a major Indian city. The patients are aged between 38 and 68 years (mean: 49.3 years) and are multiparous (mean number of children: 3.4). In this group, 61% have a history of miscarriages. Histological sections from cone biopsy are tested for the presence of high-grade human papillomavirus (HPV) using GP5+/GP6+ and MY09/MY11 primers and a set of β-globin primers. Only 33% of the cancer patients studied were positive for high-grade HPV DNA, suggesting that predisposition to cervical cancer in this cohort is not highly associated with HPV, and that other risk factors may increase the risk of cervical cancer.
ISSN:0967-4845
2474-0896
DOI:10.1080/09674845.2007.11732752