Different oral cancer scenarios to personalize targeted therapy: Boron Neutron Capture Therapy translational studies

Boron neutron capture therapy (BNCT) is a targeted therapy, which consists of preferential accumulation of boron carriers in tumor followed by neutron irradiation. Each oral cancer patient has different risks of developing one or more carcinomas and/or oral mucositis induced after treatment. Our gro...

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Bibliographic Details
Published in:Therapeutic delivery 2019-06, Vol.10 (6), p.353-362
Main Authors: Hughes, Andrea Monti, Goldfinger, Jessica A, Santa Cruz, Iara S, Pozzi, Emiliano CC, Thorp, Silvia, Curotto, Paula, Garabalino, Marcela A, Itoiz, María E, Palmieri, Mónica A, Ramos, Paula, Heber, Elisa M, Aromando, Romina F, Nigg, David W, Koivunoro, Hanna, Trivillin, Verónica A, Schwint, Amanda E
Format: Article
Language:English
Subjects:
BNCT
Boron
boron neutron capture therapy
Brain cancer
Cancer therapies
Carcinogenesis
Chemotherapy
clinical scenarios
Drug dosages
hamster cheek pouch
Head & neck cancer
Histamine
Mimicry
Mucositis
Neutrons
Oral cancer
Oral carcinoma
oral mucositis
Patients
personalized therapy
Quality of life
Radiation therapy
targeted therapy
Translation
Tumors
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Summary:Boron neutron capture therapy (BNCT) is a targeted therapy, which consists of preferential accumulation of boron carriers in tumor followed by neutron irradiation. Each oral cancer patient has different risks of developing one or more carcinomas and/or oral mucositis induced after treatment. Our group proposed the hamster oral cancer model to study the efficacy of BNCT and associated mucositis. Translational studies are essential to the advancement of novel boron delivery agents and targeted strategies. Herein, we review our work in the hamster model in which we studied BNCT induced mucositis using three different cancerization protocols, mimicking three different clinical scenarios. The BNCT-induced mucositis increases with the aggressiveness of the carcinogenesis protocol employed, suggesting that the study of different oral cancer patient scenarios would help to develop personalized therapies.
ISSN:2041-5990
2041-6008
DOI:10.4155/tde-2019-0022