The blood compatibility challenge. Part 4: Surface modification for hemocompatible materials: Passive and active approaches to guide blood-material interactions

[Display omitted] Biomedical devices in the blood flow disturb the fine-tuned balance of pro- and anti-coagulant factors in blood and vessel wall. Numerous technologies have been suggested to reduce coagulant and inflammatory responses of the body towards the device material, ranging from camouflage...

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Bibliographic Details
Published in:Acta biomaterialia 2019-08, Vol.94, p.33-43
Main Authors: Maitz, Manfred F., Martins, M. Cristina L., Grabow, Niels, Matschegewski, Claudia, Huang, Nan, Chaikof, Elliot L., Barbosa, Mário A., Werner, Carsten, Sperling, Claudia
Format: Article
Language:English
Subjects:
Anticoagulants
Bioactive coating
Biocompatibility
Biological activity
Biomedical materials
Blood flow
Blood platelets
Blood vessels
Camouflage
Coagulants
Coagulation
Control stability
Drug delivery systems
Endothelial cells
Hemocompatibility
Host systems
Immobilization
Inflammation
Medical equipment
Medical materials
Passivation
Platelets
Protein adsorption
Surface modification
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Summary:[Display omitted] Biomedical devices in the blood flow disturb the fine-tuned balance of pro- and anti-coagulant factors in blood and vessel wall. Numerous technologies have been suggested to reduce coagulant and inflammatory responses of the body towards the device material, ranging from camouflage effects to permanent activity and further to a responsive interaction with the host systems. However, not all types of modification are suitable for all types of medical products. This review has a focus on application-oriented considerations of hemocompatible surface fittings. Thus, passive versus bioactive modifications are discussed along with the control of protein adsorption, stability of the immobilization, and the type of bioactive substance, biological or synthetic. Further considerations are related to the target system, whether enzymes or cells should be addressed in arterial or venous system, or whether the blood vessel wall is addressed. Recent developments like feedback controlled or self-renewing systems for drug release or addressing cellular regulation pathways of blood platelets and endothelial cells are paradigms for a generation of blood contacting devices, which are hemocompatible by cooperation with the host system. This paper is part 4 of a series of 4 reviews discussing the problem of biomaterial associated thrombogenicity. The objective was to highlight features of broad agreement and provide commentary on those aspects of the problem that were subject to dispute. We hope that future investigators will update these reviews as new scholarship resolves the uncertainties of today.
ISSN:1742-7061
1878-7568
DOI:10.1016/j.actbio.2019.06.019