Antihepatocarcinogenic activity of whey protein concentrate and lactoferrin in diethylnitrosamine‐treated male albino mice

Hepatocellular carcinoma is considered one of the most prevalent and lethal malignancies worldwide. Chemotherapy with cytotoxic agents showed a low response rate with possible toxic effects. Recently, some emphases have been placed on the anticancer properties of bovine whey protein and its componen...

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Bibliographic Details
Published in:Environmental toxicology 2019-09, Vol.34 (9), p.1025-1033
Main Authors: Mohammed, Marwa M., Ramadan, Gamal, Zoheiry, Mona K., El‐Beih, Nadia M.
Format: Article
Language:English
Subjects:
Albinism
Anticancer properties
Antioxidants
Apoptosis
Body weight
Catalase
Chemotherapy
Cytotoxic agents
Cytotoxicity
dairy products
Diethylnitrosamine
DNA
DNA fragmentation
Glutathione
Glutathione peroxidase
Hepatocellular carcinoma
Lactoferrin
Liver
Liver cancer
liver carcinoma
Mice
Neoplasms
Peroxidase
proinflammatory cytokines
Proteins
Serum
Superoxide dismutase
Toxicity
Weight
Whey
Whey protein
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Summary:Hepatocellular carcinoma is considered one of the most prevalent and lethal malignancies worldwide. Chemotherapy with cytotoxic agents showed a low response rate with possible toxic effects. Recently, some emphases have been placed on the anticancer properties of bovine whey protein and its components, especially lactoferrin. The present study aimed to evaluate and compare the antihepatocarcinogenic activity of bovine whey protein concentrate (WPC, 300 and 600 mg/kg body weight) and lactoferrin (30 and 60 mg/kg body weight), orally and daily for 14 weeks, in the mice model of diethylnitrosamine (DEN)‐induced hepatocarcinogenesis. The results showed that both WPC and lactoferrin (in a dose‐dependent manner) alleviated significantly (P 
ISSN:1520-4081
1522-7278
DOI:10.1002/tox.22773