Clinical blood gas indices and histopathological effects of intrathecal injection of tolfenamic acid and lidocaine Hcl in donkeys

The present study aimed to investigate the clinical blood gas indices and histopathological consequences after intrathecal injection of tolfenamic acid and lidocaine Hcl and moreover, to elucidate the spinal safety of tolfenamic acid as a cyclooxygenase inhibitor in donkeys. Ten clinically healthy d...

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Bibliographic Details
Published in:Comparative clinical pathology 2020-02, Vol.29 (1), p.83-93
Main Authors: Abdelhakiem, Mohammed A. H., Abdelbaset, Abdelbaset Eweda, Abd-Elkareem, Mahmoud, Rawy, Mohamed S., Mahmoud, Hamdy F. F.
Format: Article
Language:English
Subjects:
Acids
Analgesia
Ataxia
Blood
Gases
Hematology
Injection
Lidocaine
Medical malpractice
Medicine
Medicine & Public Health
Neurodegeneration
Neurotoxicity
Oncology
Original Article
Pain perception
Paralysis
Paraplegia
Pathology
Prostaglandin endoperoxide synthase
Spinal cord
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Summary:The present study aimed to investigate the clinical blood gas indices and histopathological consequences after intrathecal injection of tolfenamic acid and lidocaine Hcl and moreover, to elucidate the spinal safety of tolfenamic acid as a cyclooxygenase inhibitor in donkeys. Ten clinically healthy donkeys were divided into two groups, 5 animals each. The first group received lidocaine Hcl 2% and the second one received tolfenamic acid 4% intrathecally. The physical parameters and ataxia, analgesia, and motor blockade scores were recorded. Blood gases and acid base balance indices and histopathological examination were done. Blood pH level was significantly decreased ( P  
ISSN:1618-5641
1618-565X
DOI:10.1007/s00580-019-03025-7