Propiconazole induces abnormal behavior and oxidative stress in zebrafish

The use of pesticides has been growing along with the demand for agricultural products. These compounds, however, are not restricted to the field, spreading easily through the soil, contaminating groundwater and reaching urban centers. Propiconazole is a triazole fungicide that has been increasingly...

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Bibliographic Details
Published in:Environmental science and pollution research international 2019-09, Vol.26 (27), p.27808-27815
Main Authors: Valadas, Jéssica, Mocelin, Ricieri, Sachett, Adrieli, Marcon, Matheus, Zanette, Régis A, Dallegrave, Eliane, Herrmann, Ana P, Piato, Angelo
Format: Article
Language:English
Subjects:
Agricultural products
Agriculture
Agrochemicals
Animals
Antifungal agents
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Brain
Catalase
Catalase - chemistry
Danio rerio
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Exposure
Fish behavior
Fungicides
Fungicides, Industrial - analysis
Fungicides, Industrial - chemistry
Groundwater
Groundwater pollution
Oxidative stress
Oxidative Stress - drug effects
Pesticides
Pesticides - analysis
Pesticides - chemistry
Propiconazole
Research Article
Sediment pollution
Soil
Soil contamination
Soil pollution
Superoxide dismutase
Superoxide Dismutase - chemistry
Triazoles
Triazoles - analysis
Triazoles - chemistry
Urban areas
Urban environments
Waste Water Technology
Water Management
Water Pollution Control
Zebrafish
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Summary:The use of pesticides has been growing along with the demand for agricultural products. These compounds, however, are not restricted to the field, spreading easily through the soil, contaminating groundwater and reaching urban centers. Propiconazole is a triazole fungicide that has been increasingly used in agriculture. However, there are few data about its effects on non-target organisms. This study aimed to evaluate the effects of propiconazole in zebrafish. The animals were exposed for 96 h to different concentrations of propiconazole (425, 850, 1700, 8500 ng/L), then submitted to the novel tank test for behavioral analyses. The brains were collected for evaluation of oxidative stress parameters. Exposure to propiconazole (1700 and 8500 ng/L) decreased the number of crossings, entries, and time spent in the top, and increased the time spent in the bottom area of the tank. We also observed an increase in the activities of superoxide dismutase and catalase in zebrafish brain exposed to propiconazole at 425, 850, and 1700 ng/L. We conclude that propiconazole alters normal fish behavior and disrupts oxidative status. More studies are necessary to elucidate the exact mechanism underlying the effects of propiconazole on non-target-organisms.
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-019-05977-3