Chemoselective metal-free indole arylation with cyclohexanones

Herein, we have revealed elemental sulfur- and iodine reagent-mediated indole C3 arylations using cyclohexanones as the arylating reagent. This protocol provides an efficient gram-scalable access to 3-arylindole and benzo[4,5]thieno[2,3-b]indole motifs with a broad range of compatible functionalitie...

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Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2019-08, Vol.6 (15), p.2738-2743
Main Authors: Lu, Chaogang, Huang, Huawen, Tuo, Xiaolong, Jiang, Pingyu, Zhang, Feng, Guo-Jun, Deng
Format: Article
Language:English
Subjects:
Cyclohexanone
Indoles
Iodine
Organic chemistry
Reagents
Sulfur
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Summary:Herein, we have revealed elemental sulfur- and iodine reagent-mediated indole C3 arylations using cyclohexanones as the arylating reagent. This protocol provides an efficient gram-scalable access to 3-arylindole and benzo[4,5]thieno[2,3-b]indole motifs with a broad range of compatible functionalities.
ISSN:2052-4110
2052-4110
DOI:10.1039/c9qo00603f