Ameliorative Effect of Zinc Oxide Nanoparticles on Nicotine Induced Testicular Dysfunction; Biochemical and Histological Study

Objective The aim of this study was to evaluate potential impact of zinc oxide nanoparticle on the possible testicular toxicity induced by nicotine. Methods 24 adult male albino rats were divided into four groups; negative control group, zinc oxide nanoparticle group: rats were received 5 mg/kg/day...

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Bibliographic Details
Published in:Toxicology and environmental health sciences 2019-06, Vol.11 (2), p.104-113
Main Authors: Mahmoud, Abeer Ramzy Hussieny, Shalaby, Nashwa Mohamad Mohamad
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Catalase
Electron microscopes
Environmental Health
Malondialdehyde
Microscopes
Nanoparticles
Nicotine
Original Article
Pharmacology/Toxicology
Testes
Testosterone
Toxicity
Zinc
Zinc oxide
Zinc oxides
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Summary:Objective The aim of this study was to evaluate potential impact of zinc oxide nanoparticle on the possible testicular toxicity induced by nicotine. Methods 24 adult male albino rats were divided into four groups; negative control group, zinc oxide nanoparticle group: rats were received 5 mg/kg/day zinc oxide nanoparticles orally, nicotine treated group: rats were administered nicotine (1 mg/kg/day) intraperitoneally and nicotine with zinc oxide nanoparticles: rats were treated with nicotine and zinc oxide nanoparticles daily for 28 days. Serum testosterone level, testicular malondialdehyde, SOD and catalase activities were measured. Testes were examined by light and electron microscopes as well. Results Significant decreases of serum testosterone level, testicular SOD and catalase activity and significant increase of testicular MDA in nicotine treated group when compared with control group were detected. Zinc oxide nanoparticles administration reversed these changes. Conclusion Zinc oxide nanoparticles ameliorated nicotine induced testicular dysfunction.
ISSN:2005-9752
2233-7784
DOI:10.1007/s13530-019-0394-4