Three-dimensional cellulose-hydroxyapatite nanocomposite enriched with dexamethasone loaded metal–organic framework: a local drug delivery system for bone tissue engineering

Three-dimensional cellulose-hydroxyapatite nanocomposite enriched with dexamethasone loaded metal–organic framework: a local drug delivery system for bone tissue engineering

Three-dimensional cellulose-hydroxyapatite nanocomposite integrated with dexamethasone loaded metal organic framework (HA/DMOF) has been synthesized as a local drug delivery system for bone tissue engineering. Initially, in situ dexamethasone encapsulated metal–organic frameworks (DMOFs) were develo...

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Bibliographic Details
Published in:Cellulose (London) 2019-08, Vol.26 (12), p.7253-7269
Main Authors: Sarkar, Chandrani, Chowdhuri, Angshuman Ray, Garai, Subhadra, Chakraborty, Jui, Sahu, Sumanta Kumar
Format: Article
Language:eng
Subjects:
Biocompatibility
Biomedical materials
Bioorganic Chemistry
Bones
Carboxymethyl cellulose
Cellulose
Ceramics
Chemistry
Chemistry and Materials Science
Composites
Compression tests
Compressive strength
Dexamethasone
Drug delivery systems
Glass
Hydroxyapatite
Mechanical properties
Metal-organic frameworks
Modulus of elasticity
Morphology
Nanocomposites
Nanoparticles
Natural Materials
Organic Chemistry
Original Research
Physical Chemistry
Polymer Sciences
Surgical implants
Sustainable Development
Synthesis
Tissue engineering
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Summary:Three-dimensional cellulose-hydroxyapatite nanocomposite integrated with dexamethasone loaded metal organic framework (HA/DMOF) has been synthesized as a local drug delivery system for bone tissue engineering. Initially, in situ dexamethasone encapsulated metal–organic frameworks (DMOFs) were developed and characterized. The synthesized DMOFs are 60–80 nm in size with rhombohedral morphology. Results showed that nearly 16% dexamethasone (Dex) was loaded in DMOFs. These synthesized DMOF nanoparticles were efficiently integrated with carboxymethyl cellulose-hydroxyapatite nanocomposite for the development of three dimensional localized drug delivery system, namely, HA/DMOF. The synthesized HA/DMOF nanocomposite was structurally characterized using various techniques. The mechanical properties of HA/DMOFs were also measured by means of compression test. It was found that the compressive strength and compressive modulus of HA/DMOF nanocomposite are 16.3 ± 1.57 MPa and 0.54 ± 0.073 GPa respectively, which are in the range of cancellous bone. In-vitro release behaviour of Dex from both DMOFs and HA/DMOFs was examined in phosphate buffered solution. It was found that Dex molecules have been released very slowly from HA/DMOF nanocomposite compared to DMOF nanoparticles, and it was sustained for 4 weeks. Cytocompatibility of HA/DMOF nanocomposite was evaluated against pre-osteoblast MC3T3 cells. It was found that the synthesized HA/DMOF nanocomposite is compatible to MC3T3 cells. Moreover, the ALP activity and extracellular mineralization capability of cells were enhanced when cultured with HA/DMOF nanocomposite. Results showed that the synthesized HA/DMOF nanocomposite is a promising material for possible therapeutic as well as load-bearing orthopedic applications. Graphic abstract
ISSN:0969-0239
1572-882X