Mesothelin, Calretinin, and Megakaryocyte Potentiating Factor as Biomarkers of Malignant Pleural Mesothelioma

Purpose Malignant pleural mesothelioma (MPM) is a highly lethal cancer caused by exposure to asbestos. Currently, the diagnosis is a challenge, carried out by means of invasive methods of limited sensitivity. This is a case–control study to evaluate the individual and combined performance of minimal...

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Bibliographic Details
Published in:Lung 2019-10, Vol.197 (5), p.641-649
Main Authors: Jiménez-Ramírez, Carmina, Casjens, Swaantje, Juárez-Pérez, Cuauhtémoc Arturo, Raiko, Irina, Del Razo, Luz M., Taeger, Dirk, Calderón-Aranda, Emma S., Rihs, Hans-Peter, Acosta-Saavedra, Leonor Concepción, Weber, Daniel Gilbert, Cabello-López, Alejandro, Pesch, Beate, Ochoa-Vázquez, María Dolores, Burek, Katarzyna, Torre-Bouscoulet, Luis, Pérez-Padilla, José Rogelio, García-Bazan, Erik Marco, Brüning, Thomas, Johnen, Georg, Aguilar-Madrid, Guadalupe
Format: Article
Language:English
Subjects:
Aged
Asbestos
Biomarkers
Biomarkers, Tumor - blood
Bone marrow cells
Calbindin 2 - blood
Calretinin
Diagnosis
Enzyme-Linked Immunosorbent Assay
Female
GPI-Linked Proteins - blood
Humans
Incidence
Lung Neoplasms - blood
Lung Neoplasms - diagnosis
Lung Neoplasms - epidemiology
Male
Medical diagnosis
Medicine
Medicine & Public Health
Men
Mesothelioma
Mesothelioma - blood
Mesothelioma - diagnosis
Mesothelioma - epidemiology
Mesothelioma, Malignant
Mexico - epidemiology
Middle Aged
Minority & ethnic groups
Pleural Disease
Pleural Neoplasms - blood
Pleural Neoplasms - diagnosis
Pleural Neoplasms - epidemiology
Pneumology/Respiratory System
Predictive Value of Tests
Prognosis
Regression analysis
Regression models
Risk Assessment
Risk Factors
Sensitivity
Sensitivity analysis
Sex Factors
Women
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Summary:Purpose Malignant pleural mesothelioma (MPM) is a highly lethal cancer caused by exposure to asbestos. Currently, the diagnosis is a challenge, carried out by means of invasive methods of limited sensitivity. This is a case–control study to evaluate the individual and combined performance of minimally invasive biomarkers for the diagnosis of MPM. Method A study of 166 incident cases of MPM and 378 population controls of Mestizo-Mexican ethnicity was conducted. Mesothelin, calretinin, and megakaryocyte potentiating factor (MPF) were quantified in plasma by ELISA. The samples were collected from 2011 to 2016. Results Based on ROC analysis and a preset specificity of 95%, the combination of the three biomarkers reached an AUC of 0.944 and a sensitivity of 82% in men. In women, an AUC of 0.937 and a sensitivity of 87% were reached. In nonconditional logistic regression models, the adjusted ORs in men were 7.92 (95% CI 3.02–20.78) for mesothelin, 20.44 (95% CI 8.90–46.94) for calretinin, and 4.37 (95% CI 1.60–11.94) for MPF. The ORs for women were 28.89 (95% CI 7.32–113.99), 17.89 (95% CI 3.93–81.49), and 2.77 (95% CI 0.47–16.21), respectively. Conclusions To our knowledge, this is the first study evaluating a combination of mesothelin, calretinin, and MPF, and demonstrating a sex effect for calretinin. The biomarker panel showed a good performance in a Mestizo-Mexican population, with high sensitivity and specificity for the diagnosis of MPM.
ISSN:0341-2040
1432-1750
DOI:10.1007/s00408-019-00244-1