Volumetric assessment of glioblastoma and its predictive value for survival

Background The objective of this study was to evaluate the morphology of glioblastoma on structural pretreatment magnetic resonance imaging (MRI), defining imaging prognostic factors. Method We conducted a retrospective analysis of MR images from 114 patients harboring a primary glioblastoma, derive...

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Bibliographic Details
Published in:Acta neurochirurgica 2019-08, Vol.161 (8), p.1723-1732
Main Authors: Henker, Christian, Hiepel, Marie Cristin, Kriesen, Thomas, Scherer, Moritz, Glass, Änne, Herold-Mende, Christel, Bendszus, Martin, Langner, Sönke, Weber, Marc-André, Schneider, Björn, Unterberg, Andreas, Piek, Jürgen
Format: Article
Language:English
Subjects:
Adult
Aged
Brain cancer
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - epidemiology
Brain Neoplasms - pathology
Brain tumors
Chemotherapy
Edema
Female
Glioblastoma
Glioblastoma - diagnostic imaging
Glioblastoma - epidemiology
Glioblastoma - pathology
Humans
Image contrast
Image processing
Interventional Radiology
Magnetic Resonance Imaging
Male
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Minimally Invasive Surgery
Necrosis
Neurology
Neuroradiology
Neurosurgery
NMR
Nuclear magnetic resonance
Original Article - Brain Tumors
Prognosis
Radiation
Segmentation
Surgical Orthopedics
Survival
Survival Analysis
Tumors
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Summary:Background The objective of this study was to evaluate the morphology of glioblastoma on structural pretreatment magnetic resonance imaging (MRI), defining imaging prognostic factors. Method We conducted a retrospective analysis of MR images from 114 patients harboring a primary glioblastoma, derived from two neurosurgical departments. Tumor segmentation was carried out in a semi-automated fashion. Tumor compartments comprised contrast-enhancing volume (CEV + ), perifocal hyperintensity on fluid-attenuated inversion recovery (FLAIR) images (FLAIR+) excluding CEV+, and a non-enhancing area within the CEV+ lesion (CEV − ). Additionally, two ratios were calculated from these volumes, the edema-tumor ratio (ETR) and necrosis-tumor ratio (NTR). All patients received surgical resection, followed by concomitant radiation and chemotherapy. Results Tumor segmentation revealed the strongest correlation between the CEV+ volume and the CEV−, presenting intratumoral necrosis ( p  
ISSN:0001-6268
0942-0940
DOI:10.1007/s00701-019-03966-6