Water-soluble extracts from edible mushrooms () as inhibitors of hepatitis C viral replication

Hepatitis C virus (HCV) is the main agent responsible for chronic liver disease. Recent advances in anti-HCV treatment strategies have significantly increased the viral clearance rate (>90%). However, sustained antiviral responses vary in different cohorts, and high costs limit the broad use of d...

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Published in:Food & function 2019-06, Vol.1 (6), p.3758-3767
Main Authors: Gallego, Paloma, Rojas, Ángela, Falcón, Gonzalo, Carbonero, Pilar, García-Lozano, María R, Gil, Antonio, Grande, Lourdes, Cremades, Olga, Romero-Gómez, Manuel, Bautista, Juan D, del Campo, José A
Format: Article
Language:English
Subjects:
Adenine
Agaricus - chemistry
Agaricus bisporus
Antiviral agents
Antiviral Agents - chemistry
Antiviral Agents - isolation & purification
Antiviral Agents - pharmacology
Basidiocarps
Fractionation
Guanine
Hepacivirus - drug effects
Hepacivirus - enzymology
Hepacivirus - genetics
Hepacivirus - physiology
Hepatitis
Hepatitis C
Hepatitis C - virology
Humans
Hypoxanthine
Inhibition
Liver diseases
Low molecular weights
Medical treatment
Molecular weight
Mushrooms
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Prophylaxis
Protease
Protease Inhibitors - chemistry
Protease Inhibitors - isolation & purification
Protease Inhibitors - pharmacology
Replication
Serine
Serine proteinase
Tandem Mass Spectrometry
Viral Nonstructural Proteins - antagonists & inhibitors
Viral Nonstructural Proteins - genetics
Viral Nonstructural Proteins - metabolism
Virus Replication - drug effects
Viruses
Water chemistry
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Summary:Hepatitis C virus (HCV) is the main agent responsible for chronic liver disease. Recent advances in anti-HCV treatment strategies have significantly increased the viral clearance rate (>90%). However, sustained antiviral responses vary in different cohorts, and high costs limit the broad use of direct-acting antivirals (DAAs). The goal of this study is to evaluate the inhibitory ability of well characterized (LC-QTOF-MS/MS) aqueous extracts obtained from edible mushrooms ( Agaricus bisporus ) to diminish HCV viral replication. Our data have demonstrated an in vitro inhibitory effect of A. bisporus extracts on NS3/4A protease and HCV replication. Fractionation by ultra-filtration and sequential liquid-liquid extraction showed that the compounds responsible for the inhibition are water-soluble with low molecular weights (
ISSN:2042-6496
2042-650X
DOI:10.1039/c9fo00733d