Over-1000 nm Near-infrared Fluorescence and SPECT/CT Dual-modal in vivo Imaging Based on Rare-earth Doped Ceramic Nanophosphors

In this study, we aimed to develop a dual-modal in vivo imaging based on over-1000 nm near-infrared (OTN-NIR) fluorescence and single photon emission computed tomography (SPECT)/computed tomography (CT). As an OTN-NIR nanophosphor material, Ytterbium and erbium ion co-doped yttrium phosphate nanopar...

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Bibliographic Details
Published in:Journal of Photopolymer Science and Technology 2016/06/21, Vol.29(4), pp.525-532
Main Authors: Kamimura, Masao, Saito, Rie, Hyodo, Hiroshi, Tsuji, Kosuke, Umeda, Izumi O., Fujii, Hirofumi, Soga, Kohei
Format: Article
Language:eng ; jpn
Subjects:
Biocompatibility
bioimaging
Block copolymers
Blood vessels
Computation
Computed tomography
Erbium
Fluorescence
In vivo methods and tests
Medical imaging
nanoparticle
Nanoparticles
Nanophosphors
near-infrared
Organs
Photon emission
poly(ethylene glycol)
Polyelectrolytes
Polyethylene glycol
Radioactivity
Rare earth elements
SPECT
Tomography
Ytterbium
Yttrium
Yttrium phosphate
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Summary:In this study, we aimed to develop a dual-modal in vivo imaging based on over-1000 nm near-infrared (OTN-NIR) fluorescence and single photon emission computed tomography (SPECT)/computed tomography (CT). As an OTN-NIR nanophosphor material, Ytterbium and erbium ion co-doped yttrium phosphate nanoparticles (YPO4 NPs) was synthesized by a hydrothermal synthesis method. Biocompatible poly(ethylene glycol) (PEG)/polycation block copolymer and radioactive 111In were introduced on the YPO4 NPs surface (PEG-111In-YPO4 NPs). The PEG-111In-YPO4 NPs showed high dispersion stability in physiological saline and excellent radioactivity in any of PBS and FBS solutions. Furthermore, in vivo OTN-NIR fluorescence and SPECT /CT imaging of live mice was performed. Strong OTN-NIR emission from the blood vessel and organs of live mice were observed. Moreover, SPECT/CT images clearly showed the three dimensional images of the live mice. Therefore, PEG-111In-YPO4 NPs is an attractive candidate for the OTN-NIR fluorescence and SPECT/CT dual-modal imaging probe, and the concept can be served as a novel platform for real-time imaging and three dimensional quantitative determinations.
ISSN:0914-9244
1349-6336
DOI:10.2494/photopolymer.29.525