Agave fructans and oligofructose decrease oxidative stress in brain regions involved in learning and memory of overweight mice

Obesity is currently a public health problem worldwide. Recently, non-reducing carbohydrates, that include β(2→1) and β(2→6) linkages in their structure, have been of particular interest in the field of obesity because they are involved in lipid metabolism. Some of these are agave fructans (AF) and...

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Bibliographic Details
Published in:Natural product research 2019-05, Vol.33 (10), p.1527-1530
Main Authors: Franco-Robles, Elena, Ramírez-Emiliano, Joel, López, Mercedes G.
Format: Article
Language:English
Subjects:
Agave - chemistry
Animals
Body weight
Brain
Brain - drug effects
Brain - metabolism
Caloric Restriction
Carbohydrates
Carbonyl compounds
Carbonyls
Cerebellum
Cortex (frontal)
Diet, High-Fat - adverse effects
Fructans
Fructans - pharmacology
Fructooligosaccharides
Lipid metabolism
Lipids
Male
Metabolism
Mice
Mice, Inbred C57BL
Obesity
Oligosaccharides - pharmacology
Overweight
Overweight - diet therapy
Overweight - etiology
Overweight - metabolism
overweight mice
Oxidative Stress
Prebiotics
Protein Carbonylation - drug effects
Public health
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Summary:Obesity is currently a public health problem worldwide. Recently, non-reducing carbohydrates, that include β(2→1) and β(2→6) linkages in their structure, have been of particular interest in the field of obesity because they are involved in lipid metabolism. Some of these are agave fructans (AF) and oligofructose (OF). In this study, we evaluated both AF and OF on oxidative stress (OS) markers in the brain of overweight mice (OM). AF and OF decreased TBARS levels and carbonyls at different levels in hippocampus (HP), frontal cortex (FC) and cerebellum (CB) of OM. The results indicated that fructans may have anti-oxidative potential and can be used as an alternative treatment for the prevention of the consequences of this pathology.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2017.1423297