Toxicological effects of comercial formulations of fungicides based on procymidone and iprodione in seedlings and root tip cells of Allium cepa

In this study the phytotoxic, cytotoxic, genotoxic and mutagenic effects of two commercial fungicide-active compounds, procymidone (PR) and iprodione (IP), were determined. The parameters evaluated were germination and root growth, mitotic index, chromosomal and nuclear aberrations, and molecular an...

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Bibliographic Details
Published in:Environmental science and pollution research international 2019-07, Vol.26 (20), p.21013-21021
Main Authors: Bernardes, Paula Mauri, Andrade-Vieira, Larissa Fonseca, Aragão, Francielen Barroso, Ferreira, Adésio, da Silva Ferreira, Marcia Flores
Format: Article
Language:English
Subjects:
Allium cepa
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Bioassays
Cell cycle
Cell death
Change detection
Cytotoxicity
Deoxyribonucleic acid
DNA
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental effects
Environmental Health
Environmental science
Formulations
Fungi
Fungicides
Genotoxicity
Germination
Iprodione
Nucleotide sequence
Pesticides
Phytotoxicity
Pollutants
Procymidone
Research Article
Seedlings
Seeds
Toxicity
Toxicology
Waste Water Technology
Water Management
Water Pollution Control
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Summary:In this study the phytotoxic, cytotoxic, genotoxic and mutagenic effects of two commercial fungicide-active compounds, procymidone (PR) and iprodione (IP), were determined. The parameters evaluated were germination and root growth, mitotic index, chromosomal and nuclear aberrations, and molecular analyses were also performed in the model plant Allium cepa L. The results demonstrated that the active compounds PR and IP were phytotoxic, delaying germination and slowing the development of A. cepa seedlings. Moreover, PR and IP showed cytogenotoxicity towards A. cepa meristematic cells, inducing chromosomal changes and cell death. The mutagenic activity of the active compounds was demonstrated by the detection of DNA changes in simple sequence repeat (SSR) and inter-simple sequence repeat (ISSR) markers in the treated cells compared to the negative control. Together, these results contribute to a better understanding of the damage caused by these substances in living organisms and reveal a promising strategy for prospective studies of the toxic effects of environmental pollutants.
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-019-04636-x