Combined coinage metal catalysis for the synthesis of bioactive molecules

The use of the coinage metals copper, silver, and gold enables an efficient and stereo-selective assembly of bioactive heterocycles via allenic intermediates. The synthesis of functionalized allenes by S 2'-substitution or S 2'-reduction is mediated or catalyzed by copper, whereas silver a...

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Bibliographic Details
Published in:Pure and applied chemistry 2010-05, Vol.82 (7), p.1529-1536
Main Authors: Krause, Norbert, Aksin-Artok, Özge, Breker, Viola, Deutsch, Carl, Gockel, Birgit, Poonoth, Manojkumar, Sawama, Yoshinari, Sawama, Yuka, Sun, Tao, Winter, Christian
Format: Article
Language:English
Subjects:
allenes
Biological activity
Catalysis
Chemical synthesis
Chirality
Copper
copper catalysis
Gold
gold catalysis
heterocycles
Silver
silver catalysis
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Summary:The use of the coinage metals copper, silver, and gold enables an efficient and stereo-selective assembly of bioactive heterocycles via allenic intermediates. The synthesis of functionalized allenes by S 2'-substitution or S 2'-reduction is mediated or catalyzed by copper, whereas silver and gold are the catalysts of choice for subsequent 5- or 6- -cyclizations. Overall, this sequence proceeds with efficient
ISSN:0033-4545
1365-3075
DOI:10.1351/PAC-CON-09-09-23