Tumor volume or dynamic contrast-enhanced MRI for prediction of clinical outcome of Ewing sarcoma family of tumors

The identification of risk factors that predict poor clinical outcome at the time of diagnosis could lead to intensified early therapy and improved outcome for pediatric patients with Ewing sarcoma family of tumors (ESFT). To compare the effectiveness of static magnetic resonance (MR) imaging measur...

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Bibliographic Details
Published in:Pediatric radiology 2001-07, Vol.31 (7), p.518-523
Main Authors: MILLER, Shannon L, HOFFER, Fredric A, REDDICK, Wilburn E, WU, Shengjie, GLASS, John O, GRONEMEYER, Suzanne A, HALILOGLU, Mithat, NIKANOROV, Alexander Y, XIAOPING XIONG, PAPPO, Alberto S
Format: Article
Language:English
Subjects:
Adolescent
Antineoplastic Agents, Alkylating - therapeutic use
Biological and medical sciences
Bone Neoplasms - drug therapy
Bone Neoplasms - pathology
Child
Child, Preschool
Clinical outcomes
Contrast Media
Cyclophosphamide - therapeutic use
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging - methods
Male
Medical sciences
Neoplasm Staging
Osteoarticular system. Muscles
Prognosis
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Randomized Controlled Trials as Topic
Regression Analysis
Retrospective Studies
Sarcoma, Ewing - drug therapy
Sarcoma, Ewing - pathology
Treatment Outcome
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Summary:The identification of risk factors that predict poor clinical outcome at the time of diagnosis could lead to intensified early therapy and improved outcome for pediatric patients with Ewing sarcoma family of tumors (ESFT). To compare the effectiveness of static magnetic resonance (MR) imaging measurements of tumor volume with variables obtained by dynamic contrast-enhanced MR imaging (DEMRI) in predicting ESFT outcome. MR examinations that included DEMRI were retrospectively reviewed. The analyses included 45 examinations of 21 patients with ESFT (performed from 1992 to 1996). Tumor volumes were measured on the static MR images, and the regions of interest were selected for DEMRI analysis. The relationships of static MR imaging and DEMRI variables with the probability of progression-free survival (PFS) and disease-free survival (DFS) were determined. Larger tumor volume at the time of diagnosis predicted poorer PFS and DFS estimates. No DEMRI variable predicted outcome. Determination of tumor volume by static MR imaging at the time of diagnosis is a simple and reliable method of predicting the clinical outcome of patients with ESFT. DEMRI is not as reliable a technique as static MR imaging for predicting the outcome of these patients.
ISSN:0301-0449
1432-1998
DOI:10.1007/s002470100481