Risk factors for postoperative delirium after gastrointestinal surgery - using randomized Phase II trial data

Background/Aim: Postoperative delirium is a common complication which is associated with increased postoperative mortality and morbidity. The aim of this study was to evaluate the incidence and predictors of postoperative delirium using data from a phase II clinical trial.Patients and Methods: We an...

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Published in:Annals of Cancer Research and Therapy 2018/08/02, Vol.26(2), pp.95-100
Main Authors: Kamiya, Mariko, Aoyama, Toru, Kano, Kazuki, Murakawa, Masaaki, Kazama, Keisuke, Atsumi, Yosuke, Maezawa, Yukio, Sawazaki, Sho, Numata, Masakatsu, Taguri, Masataka, Tamagawa, Hiroshi, Sugano, Nobuhiro, Sato, Tsutomu, Mushiake, Hiroyuki, Yukawa, Norio, Oshima, Takashi, Masuda, Munetaka, Rino, Yasushi
Format: Article
Language:English
Subjects:
Clinical trials
Delirium
gastrointestinal malignancy
Health risk assessment
Mental disorders
MMSE
Morbidity
Patients
postoperative delirium
Risk factors
Surgery
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Summary:Background/Aim: Postoperative delirium is a common complication which is associated with increased postoperative mortality and morbidity. The aim of this study was to evaluate the incidence and predictors of postoperative delirium using data from a phase II clinical trial.Patients and Methods: We analyzed the cases that were enrolled in randomized clinical trial to evaluate TJ-54 (Yokukansan, a traditional Japanese medicine [Kampo]) for the prevention and/or treatment of postoperative delirium (UMIN000005423). The Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) was used to diagnose postoperative delirium.Results: A total of 167 patients were registered, delirium was observed in 9% of them. High age over 80 and low MMSE less than 27 were identified as significant independent risk factors.Conclusion: Surgeon should pay attention to the possible development of postoperative delirium in patients aged over 80 with a low MMSE less than 27 in performing surgery for gastrointestinal malignancies.
ISSN:1344-6835
1880-5469
DOI:10.4993/acrt.26.95