Relative Safety of Sexual Lubricants for Rectal Intercourse

Objective: The current study was conducted to determine the relative safety of sexual lubricants for rectal use. Goal: Our goal was to identify a sexual lubricant that would not damage the rectal epithelium. Study Design: We describe a mouse assay to determine the degree to which lubricants cause re...

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Bibliographic Details
Published in:Sexually transmitted diseases 2004-06, Vol.31 (6), p.346-349
Main Authors: SUDOL, KRISTIN M., PHILLIPS, DAVID M.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Epithelial Cells - drug effects
Female
General aspects
Herpes viruses
Herpesvirus 2, Human - drug effects
Human infectious diseases. Experimental studies and models
Infectious diseases
Lubricants & lubrication
Lubrication
Medical sciences
Mice
Mice, Inbred BALB C
Microbial Sensitivity Tests
Models, Animal
Rectum - cytology
Rectum - drug effects
Sexual Behavior
Sexually transmitted diseases
STD
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Summary:Objective: The current study was conducted to determine the relative safety of sexual lubricants for rectal use. Goal: Our goal was to identify a sexual lubricant that would not damage the rectal epithelium. Study Design: We describe a mouse assay to determine the degree to which lubricants cause rectal sloughing. We also tested lubricants for cytotoxicity and their effect on Herpes simplex virus (HSV-2) infection after rectal challenge. Results: Of the products tested, Delube and KY-Plus are most likely to damage the rectal epithelium, whereas Viamor, Vagisil, and Astroglide would cause some degree of rectal damage. PBS, Carraguard, and methylcellulose were not toxic in any of the assays. Conclusion: We have developed a quantitative method to assay the degree of sloughing of the rectal epithelium. Using this and other techniques, we are able to predict the degree to which lubricants could be safe for rectal use.
ISSN:0148-5717
1537-4521
DOI:10.1097/00007435-200406000-00005