Antimicrobial Resistance in Neisseria gonorrhoeae in Finland, 1976 to 1995

Background and Objectives: The worldwide increase in antimicrobial resistance in Neisseria gonorrhoeae prompted the authors to evaluate the status and course of resistance in gonococci in Finland. Goals: The minimal inhibitory concentrations (MIC) of penicillin, tetracycline, spectinomycin, ciproflo...

Full description

Saved in:
Bibliographic Details
Published in:Sexually transmitted diseases 1997-11, Vol.24 (10), p.576-581
Main Authors: NISSINEN, ANTTI, JÄRVINEN, HELINÄ, LIIMATAINEN, OILI, JAHKOLA, MATTI, HUOVINEN, PENTTI
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
History
Medical sciences
Pharmacology. Drug treatments
Sexually transmitted diseases
STD
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and Objectives: The worldwide increase in antimicrobial resistance in Neisseria gonorrhoeae prompted the authors to evaluate the status and course of resistance in gonococci in Finland. Goals: The minimal inhibitory concentrations (MIC) of penicillin, tetracycline, spectinomycin, ciprofloxacin, ceftriaxone, and cefixime were tested for 337 consecutive clinical N. gonorrhoeae isolates collected in 19 Finnish microbiology laboratories in 1993. Study Design: The results were compared with data obtained in three Finnish laboratories in 1986 and contrasted with the development of the incidence of gonorrhea and the prevalence of penicillinase-producing N. gonorrhoeae (PPNG) in Finland, 1976 to 1995. The number of strains with an elevated MIC to ciprofloxacin was assessed by questionnaire. Results: A decrease, from more than 50% in 1986 to 20% in 1993, of strains susceptible to penicillin and tetracycline was observed. The prevalence of PPNG increased from 0% (1976) to 5.7% (1995). In 1995, two strains with a ciprofloxacin MIC of ≥ 32 µg/ml were reported. No resistance to ceftriaxone or spectinomycin was detected. Conclusions: In spite of the rarity of gonorrhea and the availability of efficient antimicrobials in Finland, monitoring of the antimicrobial resistance of N. gonorrhoeae remains important.
ISSN:0148-5717
1537-4521
DOI:10.1097/00007435-199711000-00005