Short-term exercise improves myocardial tolerance to in vivo ischemia-reperfusion in the rat

Department of Exercise and Sport Sciences and Physiology and the Center for Exercise Science, University of Florida, Gainesville, Florida 32611 These experiments examined the independent effects of short-term exercise and heat stress on myocardial responses during in vivo ischemia-reperfusion (I/R)....

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2001-11, Vol.91 (5), p.2205-2212
Main Authors: Demirel, Haydar A, Powers, Scott K, Zergeroglu, Murat A, Shanely, R. Andrew, Hamilton, Karyn, Coombes, Jeff, Naito, Hisashi
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Antioxidants - metabolism
Biological and medical sciences
Blood Pressure - physiology
Cardiology. Vascular system
Coronary heart disease
Coronary Vessels - physiology
Exercise
Female
Heart
Heart - physiopathology
Heat
Heat-Shock Proteins - metabolism
Hot Temperature
HSP72 Heat-Shock Proteins
Medical sciences
Myocardial Reperfusion Injury - metabolism
Myocardial Reperfusion Injury - pathology
Myocardial Reperfusion Injury - physiopathology
Myocardium - metabolism
Myocardium - pathology
Physical Conditioning, Animal - physiology
Physical Exertion - physiology
Rats
Rats, Sprague-Dawley
Rodents
Stress, Psychological - pathology
Stress, Psychological - physiopathology
Ventricular Dysfunction, Left
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Summary:Department of Exercise and Sport Sciences and Physiology and the Center for Exercise Science, University of Florida, Gainesville, Florida 32611 These experiments examined the independent effects of short-term exercise and heat stress on myocardial responses during in vivo ischemia-reperfusion (I/R). Female Sprague-Dawley rats (4   mo old) were randomly assigned to one of four experimental groups: 1 ) control, 2 ) 3 consecutive days of treadmill exercise [60 min/day at 60-70% maximal O 2 uptake ( O 2 max )], 3 ) 5 consecutive days of treadmill exercise (60 min/day at 60-70% O 2 max ), and 4 ) whole body heat stress (15 min at 42°C). Twenty-four hours after heat stress or exercise, animals were anesthetized and mechanically ventilated, and the chest was opened by thoracotomy. Coronary occlusion was maintained for 30-min followed by a 30-min period of reperfusion. Compared with control, both heat-stressed animals and exercised animals (3 and 5 days) maintained higher ( P  
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.2001.91.5.2205