Effect of toluene and nutritional status on serotonin, lipid peroxidation levels and NA+/K+-ATPase in adult rat brain

The aim was to evaluate the effect of toluene and nutritional status on levels of serotonin (5-HT), 5-hydroxytryptophan (5-HTP), Na+/K+-ATPase, total ATPase and lipid peroxidation (TBARS) in rat brain. Study was conducted with malnourished (MN), well-nourished (WN) and normal Wistar rats. Three grou...

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Bibliographic Details
Published in:Neurochemical research 2005-05, Vol.30 (5), p.619-624
Main Authors: Calderón-Guzmán, David, Espitia-Vázquez, Ivonne, López-Domínguez, Alejandra, Hernández-García, Ernestina, Huerta-Gertrudis, Bernardino, Coballase-Urritia, Elvia, Juárez-Olguín, Hugo, García-Fernández, Beatriz
Format: Article
Language:English
Subjects:
Animals
Brain - drug effects
Brain - enzymology
Brain - metabolism
Lipid Peroxidation - drug effects
Longitudinal Studies
Male
Nutritional Status
Prospective Studies
Rats
Rats, Wistar
Serotonin - metabolism
Sodium-Potassium-Exchanging ATPase - metabolism
Toluene - toxicity
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Summary:The aim was to evaluate the effect of toluene and nutritional status on levels of serotonin (5-HT), 5-hydroxytryptophan (5-HTP), Na+/K+-ATPase, total ATPase and lipid peroxidation (TBARS) in rat brain. Study was conducted with malnourished (MN), well-nourished (WN) and normal Wistar rats. Three groups were formed for each nutritional status: control group I received 0.9% NaCl; toluene (1 g/kg) was administered to group II, and 1.5 g/kg to group III. Levels of 5-HT decreased (P < 0.05) in WN toluene groups, and 5-HTP decreased (P < 0.05) in the WN 1 g toluene and MN 1.5 g toluene groups. TBARS decreased (P < 0.05) in WN toluene groups. A trend to increase in Na+/K+-ATPase was found in WN and MN toluene groups, while total ATPase increased (P < 0.05) in the WN 1.5 g toluene group. The results suggest that high concentrations of toluene in single doses induce significant changes in the serotonergic system and alter membrane fluidity more perceptibly in the brain of adult animals with regular diet than in malnourished animals.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-005-2749-2