Molecularly imprinted paper-based analytical device obtained by a polymerization-free synthesis

[Display omitted] •Molecularly imprinted paper-based sensor was prepared via polymerization-free method.•The synthesis was carried out by dissolving nylon-6 in formic acid.•The use of filter paper increases the versatility and manageability of the material.•Sensor was evaluated by extracting aqueous...

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Bibliographic Details
Published in:Sensors and actuators. B, Chemical Chemical, 2019-05, Vol.287, p.138-146
Main Authors: Díaz-Liñán, M.C., López-Lorente, A.I., Cárdenas, S., Lucena, R.
Format: Article
Language:English
Subjects:
Addition polymerization
Cellulose paper
Chemical synthesis
Filter paper
Fluorescence
Fluorometers
Microextraction
Molecular imprinting
Molecularly imprinted polymer
Norfloxacin
Nylon-6
Paper-based analytical device
Polymerization
Polymers
Quantitative analysis
Quinine
Reproducibility
Selectivity
Target recognition
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Summary:[Display omitted] •Molecularly imprinted paper-based sensor was prepared via polymerization-free method.•The synthesis was carried out by dissolving nylon-6 in formic acid.•The use of filter paper increases the versatility and manageability of the material.•Sensor was evaluated by extracting aqueous solutions of quinine and a soda drink.•Molecularly imprinted paper-based analytical device can be reused at least six times. In the last years, the imprinting technology has raised attention and different polymers with artificial recognition sites towards a target molecule have been developed. In this article, a polymerization-free method ―which only requires the dissolution of nylon-6 polymer and its subsequent incubation with the template molecule― has been employed for the preparation of a molecularly imprinted polymer directly immobilized on filter paper, thus increasing the versatility and manageability of the new material. The molecularly imprinted paper-based analytical device (MIP PAD) has been coupled to a fluorimeter via a custom-built platform, which enables direct measurement of the fluorescence at the surface of the MIP PAD. Extraction efficiency of the MIP PAD was evaluated using quinine as model analyte, measuring the fluorescence directly at the MIP PAD surface after incubation on aqueous standards of quinine and soda drink, showing that the performance of the imprinted material was superior to that of the non-imprinted polymer. In addition, the selectivity of the MIP PAD versus analogous organic fluorescent molecules has been further evaluated using norfloxacin, observing that the molecular imprinting results in selective extraction of quinine. The performance of the method has been evaluated for quantitative analysis, achieving limits of detection (LOD) and quantification (LOQ) for aqueous standards of 0.37 and 1.24 mg L−1, respectively, while in the case of spiked soda drink the LOD and LOQ were 0.63 and 2.11 mg L−1, respectively. The reproducibility of the measurements was also evaluated, observing values within range 2.30 and 9.07% measured as relative standard deviation.
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2019.02.048