Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect

Aim: N-acetyl-L-cysteine (NAC) is a free radical scavenger. We developed NAC-coated Ag2S (NAC-Ag2S) quantum dot (QD) as an optical imaging and therapeutic agent. Materials & methods: QDs were synthesized in water. Their optical imaging potential and toxicity were studied in vitro. Results: NAC-A...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2019-04, Vol.14 (8), p.969
Main Authors: Pelin Turhan Buz, Fatma Demir Duman, Erkisa, Merve, Demirci, Gozde, Ferda Ari, Ulukaya, Engin, Havva Yagci Acar
Format: Article
Language:English
Subjects:
Antioxidants
Apoptosis
Bioavailability
Biocompatibility
Cancer
Cell cycle
Cervical cancer
Chemical bonds
Chronic obstructive pulmonary disease
Cytotoxicity
Deoxyribonucleic acid
DNA
DNA damage
Free radicals
Kinases
Luminescence quenching
Oxidative stress
Protective coatings
Quantum dots
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Summary:Aim: N-acetyl-L-cysteine (NAC) is a free radical scavenger. We developed NAC-coated Ag2S (NAC-Ag2S) quantum dot (QD) as an optical imaging and therapeutic agent. Materials & methods: QDs were synthesized in water. Their optical imaging potential and toxicity were studied in vitro. Results: NAC-Ag2S QDs have strong emission, that is tunable between 748 and 840 nm, and are stable in biologically relevant media. QDs showed significant differences both in cell internalization and toxicity in vitro. QDs were quite toxic to breast and cervical cancer cells but not to lung derived cells despite the higher uptake. NAC-Ag2S reduces reactive oxygen species (ROS) but causes cell death via DNA damage and apoptosis. Conclusion: NAC-Ag2S QDs are stable and strong signal-generating theranostic agents offering selective therapeutic effects.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2018-0214