Frontispiece: Resurrection and Reactivation of Acetylcholinesterase and Butyrylcholinesterase

Despite extensive quantities of work with regard to reactivation of organophosphorus‐inhibited and aged acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), a new therapeutic solution has yet to be reached and current methods continue to rely on old oximes and management of the cholinergic...

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Bibliographic Details
Published in:Chemistry : a European journal 2019-04, Vol.25 (21), p.n/a
Main Authors: Franjesevic, Andrew J., Sillart, Sydney B., Beck, Jeremy M., Vyas, Shubham, Callam, Christopher S., Hadad, Christopher M.
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Activation
butyrylcholinesterase
Chemistry
Cholinergics
organophosphorus
Oximes
reactivation
resurrection
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Summary:Despite extensive quantities of work with regard to reactivation of organophosphorus‐inhibited and aged acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), a new therapeutic solution has yet to be reached and current methods continue to rely on old oximes and management of the cholinergic crisis as the standard of care. For more information on the latest developments in this highly important field see the Review article by C. M. Hadad et al. on page 5337 ff.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201982161