Gel-liquid crystal phase transition in dry and hydrated SOPC phospholipid studied by differential scanning calorimetry

We study the thermodynamic properties of pure and hydrated samples of SOPC (stearoyl-2-oleoyl-sn-glycero-3-phosphocholine) membrane via Differential Scanning Calorimetry. We estimate the fundamental thermodynamic quantities, such as enthalpy and entropy, of the bilayer phosphatidylcholine. It is fou...

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Bibliographic Details
Published in:Phase transitions 2019-04, Vol.92 (4), p.323-333
Main Authors: Genova, Julia, Slavkova, Zdravka, Chamati, Hassan, Petrov, Minko
Format: Article
Language:English
Subjects:
Calorimetry
Computer simulation
Differential scanning calorimetry
Enthalpy
Entropy
Heat measurement
Heating rate
hydration
Hydrogen bonding
Liquid crystals
Molecular dynamics
phase transition
Phase transitions
Phospholipids
Thermodynamic properties
Transition temperature
Transition temperatures
Water chemistry
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Summary:We study the thermodynamic properties of pure and hydrated samples of SOPC (stearoyl-2-oleoyl-sn-glycero-3-phosphocholine) membrane via Differential Scanning Calorimetry. We estimate the fundamental thermodynamic quantities, such as enthalpy and entropy, of the bilayer phosphatidylcholine. It is found that the gel-liquid crystal phase transition is driven by the van't Hoff enthalpy, revealing the occurrence of an intermediate phase transition. We discuss the influence of the heating rate on the enthalpy and on the gel ↔ liquid crystal phase transition temperature by introducing the adequate thermodynamic Gibbs potential. The effect of hydrogen bonding of the water molecules with the polar head and polar-apolar interface on the energetics of the bilayer membrane matrix is analysed. The obtained transition temperature was found to vary between 3 and 4°C depending on the hydration level. A result corroborated by the behaviour of the heat capacity of SOPC computed via Molecular dynamics simulation.
ISSN:0141-1594
1029-0338
DOI:10.1080/01411594.2019.1580368