The relationship between Multidrug Resistance Protein 1(rs1045642) and Cholesterol 24-hydroxylase (rs754203) genes polymorphism with type 2 diabetes mellitus

Background: The involvement of genetic factors like gene polymorphisms has been found to contribute significantly to the development and progression of type 2 diabetes (T2DM). Thousands of single nucleotide polymorphisms in various genes have been found to be associated with risk of T2DM. The presen...

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Published in:British journal of biomedical science 2017-01, Vol.74 (1), p.30-35
Main Authors: Rizvi, Saliha, Raza, Syed Tasleem, Mehdi, S. Riyaz, Siddiqi, Zeba, Eba, Ale, Mahdi, Farzana
Format: Article
Language:English
Subjects:
Alleles
Blood pressure
Cholesterol
CYP46A1
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Gene frequency
Gene polymorphism
Genes
Genetic factors
Hydroxylase
MDR1
MDR1 protein
Multidrug resistance
Multidrug resistant organisms
P-Glycoprotein
Polymorphism
Single-nucleotide polymorphism
Sugar
type 2 diabetes mellitus
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Summary:Background: The involvement of genetic factors like gene polymorphisms has been found to contribute significantly to the development and progression of type 2 diabetes (T2DM). Thousands of single nucleotide polymorphisms in various genes have been found to be associated with risk of T2DM. The present study was aimed to investigate association of Multidrug resistance 1 (MDR1) (rs1045642) and CYP46A1 (rs754203) genes polymorphism with T2DM. Subjects & Methods: Study includes 333 subjects, 183 T2DM cases and 150 healthy controls. Single nucleotide polymorphism was evaluated by PCR-PFLP. Alleles and genotype frequencies between cases and controls were compared using χ2 and Student's t-tests. Odds ratios and 95% confidence intervals were calculated by logistic regression to assess the relative association between disease and genotypes. Results: In case of CYP46A1 gene, CC (p 
ISSN:0967-4845
2474-0896
DOI:10.1080/09674845.2016.1264212