Nephroprotective Potential of Alstonia scholaris in Cisplatin Induced Nephrotoxicity in Experimental Animals

The present investigation was aimed to determine the alterations in antioxidant, biochemical and histopathological parameters in cisplatin (cDDP) induced nephrotoxicity and its protection by treatments with aqueous and ethanolic leaf extracts of Alstonia scholaris . Acute nephrotoxicity was induced...

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Bibliographic Details
Published in:National Academy of Sciences, India. Proceedings. Section B. Biological Sciences India. Proceedings. Section B. Biological Sciences, 2019-03, Vol.89 (1), p.43-52
Main Authors: Verma, Pawan K., Raina, Rajinder, Sultana, Mudasir, Singh, Maninder, Kumar, Pawan
Format: Article
Language:English
Subjects:
Alstonia scholaris
Antioxidants
Behavioral Sciences
Biomedical and Life Sciences
Blood levels
Cisplatin
Creatinine
Enzymes
Glutathione
Kidneys
Leaves
Life Sciences
Malondialdehyde
Nucleic Acid Chemistry
Oxidative stress
Peritoneum
Plant Biochemistry
Plasma proteins
Quercetin
Research Article
Rodents
Thiols
Urea
Uric acid
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Summary:The present investigation was aimed to determine the alterations in antioxidant, biochemical and histopathological parameters in cisplatin (cDDP) induced nephrotoxicity and its protection by treatments with aqueous and ethanolic leaf extracts of Alstonia scholaris . Acute nephrotoxicity was induced by single intra-peritoneal administration of cDDP (12 mg kg −1 ) in wistar rats. Nephrotoxic rats were treated with quercetin (50 mg kg −1 ), aqueous and ethanolic leaf extracts (300 mg kg −1 ) by oral gavage. Cisplatin treatment elevated ( P  
ISSN:0369-8211
2250-1746
DOI:10.1007/s40011-017-0881-9