Osteonecrosis of the jaw induced by oral administration of bisphosphonates in Asian population: five cases

Summary Bisphosphonate-related osteonecrosis of the jaw (BRONJ) can occur irrespective of race. Old age and long-term use of corticosteroid may be a more reliable risk factor than racial characteristics. Introduction BRONJ is an increasingly common problem. Most BRONJ occurs following an intravenous...

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Bibliographic Details
Published in:Osteoporosis international 2010-03, Vol.21 (3), p.527-533
Main Authors: Park, W, Kim, N.-K, Kim, M.-Y, Rhee, Y.-M, Kim, H. J
Format: Article
Language:English
Subjects:
Administration, Oral
Aged
Aged, 80 and over
Asian people
Biological and medical sciences
Bone Density Conservation Agents - adverse effects
Bone diseases
Bones, joints and connective tissue. Antiinflammatory agents
Case Report
Diphosphonates - adverse effects
Diseases of the osteoarticular system
Drug therapy
Endocrinology
Female
Humans
Jaw Diseases - chemically induced
Jaw Diseases - diagnostic imaging
Medical sciences
Medicine
Medicine & Public Health
Mouth
Older people
Orthopedics
Osteonecrosis - chemically induced
Osteonecrosis - diagnostic imaging
Osteoporosis. Osteomalacia. Paget disease
Pharmacology. Drug treatments
Radiography, Panoramic
Rheumatology
Risk factors
Tomography, X-Ray Computed
Vascular bone diseases
Women
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Summary:Summary Bisphosphonate-related osteonecrosis of the jaw (BRONJ) can occur irrespective of race. Old age and long-term use of corticosteroid may be a more reliable risk factor than racial characteristics. Introduction BRONJ is an increasingly common problem. Most BRONJ occurs following an intravenous administration of bisphosphonate treatment for malignant bone disease and metastatic cancer. As the incidence of BRONJ caused by oral administration of bisphosphonate is quite low, it is believed that this medication is relatively safe and effective in preventing complications of osteoporosis, such as hip or spine fractures. The many known risk factors for BRONJ can be classified as drug-related, local, demographic, and systemic. One demographic and systemic risk factor is race. Most of the case reports of BRONJ present elderly, white women. Methods In this report, we describe five cases of BRONJ caused by oral administration of bisphosphonate in Asian population. Results All the patients were female and over 65 years old. Three patients had been prescribed with corticosteroids for rheumatoid arthritis. Conclusion Irrespective of race, elderly women undergoing steroid therapy have an increased incidence of BRONJ even with oral administration of bisphosphonate.
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-009-0973-3