Serum zinc and its relation to bone mineral density in [beta]-thalassemic adolescents

Trace elements have been considered to play critical roles in bone metabolism. This study aims at determining the serum zinc profile and its association with bone mineral density (BMD) abnormalities in thalassemic patients. In 131 transfusion-dependent β-thalassemic patients, aged 10-20 yr, serum le...

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Bibliographic Details
Published in:Biological trace element research 2004-03, Vol.97 (3), p.215
Main Authors: Bekheirnia, Reza, Shamshirsaz, Alireza Abdollah, Kamgar, Mohammad, Bouzari, Navid, Erfanzadeh, Ghazaleh, Pourzahedgilani, Nima, Tabatabaie, Seyed Mahmood, Shamshirsaz, Amirhooshang Abdollah, Kimiagar, Masood, Ezzati, Fatemeh, Larijani, Bagher
Format: Article
Language:English
Subjects:
Bone density
Bones
Diet
Teenagers
Zinc
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Summary:Trace elements have been considered to play critical roles in bone metabolism. This study aims at determining the serum zinc profile and its association with bone mineral density (BMD) abnormalities in thalassemic patients. In 131 transfusion-dependent β-thalassemic patients, aged 10-20 yr, serum levels of zinc were measured by flame atomic absorption spectrophotometry (F-AAS). BMD values at the lumbar (L1-L4) and femoral neck were determined by dual X-ray absorptiometry (DXA). Dietary zinc intake and daily consumption of calcium were evaluated by a food-frequency questionnaire. Low serum zinc was found in 84.8% (in 44.7% severely low). Below -2 BMD Z-scores were observed in 68.7% and 17.6% of the patients at the lumbar and femoral regions, respectively. Female patients with severe zinc deficiency had lower lumbar BMD Z-scores in comparison to the other females (-3.26 vs -2.54). Serum zinc in females with femoral BMD Z-scores
ISSN:0163-4984
1559-0720
DOI:10.1385/BTER:97:3:215