Biohybrid catalysts for sequential one-pot reactions based on an engineered transmembrane protein

A one-pot cascade reaction sequence to obtain 1,2-diarylethanes from styrenes was developed. The cascade reaction comprises an olefin cross metathesis and a hydrogenation step with two biohybrid catalysts. One biohybrid catalyst is based on the engineered transmembrane protein FhuA harboring a Grubb...

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Bibliographic Details
Published in:Catalysis science & technology 2019, Vol.9 (4), p.942-946
Main Authors: Sauer, D. F., Qu, Y., Mertens, M. A. S., Schiffels, J., Polen, T., Schwaneberg, U., Okuda, J.
Format: Article
Language:English
Subjects:
Cascade chemical reactions
Catalysis
Catalysts
Metathesis
Proteins
Rhodium
Ruthenium
Styrenes
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Summary:A one-pot cascade reaction sequence to obtain 1,2-diarylethanes from styrenes was developed. The cascade reaction comprises an olefin cross metathesis and a hydrogenation step with two biohybrid catalysts. One biohybrid catalyst is based on the engineered transmembrane protein FhuA harboring a Grubbs–Hoveyda-type ruthenium carbene complex and the other one harbors a rhodium( i ) complex. Both active sites are covalently anchored via a modified N-heterocyclic carbene (NHC).
ISSN:2044-4753
2044-4761
DOI:10.1039/C8CY02236D