Electrochemical determination of disulfoton using a molecularly imprinted poly-phenol polymer

A simple, rapid and sensitive electrochemical method using a molecularly imprinted poly-phenol polymer for the analysis of disulfoton in model and real samples is demonstrated. A computational approach to molecularly imprinted polymer design and screening is followed using density functional (B3LYP)...

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Bibliographic Details
Published in:Electrochimica acta 2019-02, Vol.295, p.333-339
Main Authors: Qader, Bakhtiyar, Baron, Mark, Hussain, Issam, Sevilla, J.M., Johnson, Robert P., Gonzalez-Rodriguez, Jose
Format: Article
Language:English
Subjects:
Blood plasma
Computational chemistry
Disulfoton
Electrochemistry
Electrodes
Electrons
Empirical analysis
Glassy carbon
Linearity
Molecular imprinting
Molecularly imprinted polymer
Oxidation
Pesticides
Phenols
Polymers
Silver chloride
Urine
Voltammetry
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Summary:A simple, rapid and sensitive electrochemical method using a molecularly imprinted poly-phenol polymer for the analysis of disulfoton in model and real samples is demonstrated. A computational approach to molecularly imprinted polymer design and screening is followed using density functional (B3LYP) and Semi-Empirical Parameterized Model number 3 (PM3) models. The selected phenol monomer is electrochemically polymerized by cyclic voltammetry at a glassy carbon working electrode in the presence of a disulfoton template. The subsequent molecularly imprinted polymer sensor exhibits an oxidation peak at 1.13 V vs. Ag/AgCl in cyclic voltammetry with excellent linearity (r2 = 0.9985) over the range 1–30 μM. The limit of detection for the DSN-MIP is 0.183 μM, compared to a limit of detection of 1.64 μM with cyclic voltammetry for the bare glassy carbon electrode. Intra- and inter-day assay precisions, expressed as relative standard deviation, are both found to be less than 7% overall. The developed molecularly imprinted polymer sensor is utilized to determine disulfoton in both spiked synthetic human plasma and human urine samples with recoveries ranging from 85.2% to 101.1%. The developed methods can be applied for measuring this toxicant in a real sample.
ISSN:0013-4686
1873-3859
DOI:10.1016/j.electacta.2018.10.127