Tools for Combinatorial Chemistry:  Real-Time Single-Bead Infrared Analysis of a Resin-Bound Photocleavage Reaction

The feasibility of using infrared spectroscopy for the real-time, in situ analysis of resin-bound photocleavable linkers from a single bead is illustrated using infrared microscopy. Results indicate this technique to be an extremely powerful tool for the analysis of photocleavage reactions directly...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 1997-09, Vol.69 (18), p.3851-3853
Main Authors: Pivonka, Don E, Simpson, Thomas R
Format: Article
Language:English
Subjects:
Chemistry
Exact sciences and technology
General and physical chemistry
Infrared radiation
Photochemistry
Physical chemistry of induced reactions (with radiations, particles and ultrasonics)
Resins
Scientific imaging
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Summary:The feasibility of using infrared spectroscopy for the real-time, in situ analysis of resin-bound photocleavable linkers from a single bead is illustrated using infrared microscopy. Results indicate this technique to be an extremely powerful tool for the analysis of photocleavage reactions directly on the solid-phase support. This report further details methodology providing a very high degree of automation to eliminate many of the sampling problems associated with batch analysis.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac9700843