The effect of semax and the C-terminal peptide PGP on expression of growth factor genes and receptors in rats under conditions of experimental cerebral ischemia

To understand the molecular mechanisms of the neuroprotective effect of semax in cerebral ischemia, a study analyzed for the first time the effect of semax and the C-terminal tripeptide PGP on the expression of mRNAs of 84 genes that control growth factors and their receptors under conditions of the...

Full description

Saved in:
Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2008-10, Vol.422 (1), p.261-264
Main Authors: Dmitrieva, V. G., Dergunova, L. V., Povarova, O. V., Skvortsova, V. I., Limborskaya, S. A., Myasoedov, N. F.
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - administration & dosage
Adrenocorticotropic Hormone - analogs & derivatives
Animals
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Brain Ischemia - metabolism
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Dose-Response Relationship, Drug
Gene Expression - drug effects
Genetics
Life Sciences
Male
Molecular Biology
Nerve Growth Factors - metabolism
Neurons
Neuroprotective Agents - administration & dosage
Oligopeptides - administration & dosage
Peptide Fragments - administration & dosage
Peptides
Proline - administration & dosage
Proline - analogs & derivatives
Rats
Rats, Wistar
Receptors, Nerve Growth Factor - metabolism
Rodents
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To understand the molecular mechanisms of the neuroprotective effect of semax in cerebral ischemia, a study analyzed for the first time the effect of semax and the C-terminal tripeptide PGP on the expression of mRNAs of 84 genes that control growth factors and their receptors under conditions of the experimental focal cerebral ischemia of rats. Results suggest that two-type growth factors serve as targets for semax and PGP: the nervous tissue (neurons and glial cells) and the vessel wall cells. The neuroprotective effects of semax and PGP on the ischemic brain could be related to their inuence on the expression of the growth factor genes and receptors responsible for the function of nervous tissue and vessels.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672908050037