Spatially Resolved MR-Compatible Doppler Ultrasound: Proof of Concept for Triggering of Diagnostic Quality Cardiovascular MRI for Function and Flow Quantification at 3T

Objective: We demonstrate the use of a magnetic-resonance (MR)-compatible ultrasound (US) imaging probe using spatially resolved Doppler for diagnostic quality cardiovascular MR imaging (MRI) as an initial step toward hybrid US/MR fetal imaging. Methods: A newly developed technology for a dedicated...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2018-02, Vol.65 (2), p.294-306
Main Authors: Crowe, Lindsey Alexandra, Salomir, Rares, Manasseh, Gibran, Chmielewski, Aneta, Hachulla, Anne-Lise, Speicher, Daniel, Greiser, Andreas, Muller, Hajo, de Perrot, Thomas, Vallee, Jean-Paul
Format: Article
Language:English
Subjects:
Adult
Aorta
Cardiac function
Cardiac Imaging Techniques - methods
Color
Compatibility
Data acquisition
Diagnostic systems
Doppler effect
Doppler ultrasound
ECG
Ejection
EKG
Electrocardiography
Feasibility studies
Female
Fetuses
Flow
Gating
Heart
Heart - diagnostic imaging
Hemodynamics
Humans
Image acquisition
Image color analysis
Image processing
Image quality
Interference
Magnetic fields
Magnetic resonance imaging
Magnetic Resonance Imaging, Cine - methods
Male
Medical imaging
metric optimized gating
MRI
Oligodendrocyte-myelin glycoprotein
Sharpness
Transducers
Ultrasonic imaging
Ultrasonography, Doppler - methods
Ultrasound
Young Adult
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Summary:Objective: We demonstrate the use of a magnetic-resonance (MR)-compatible ultrasound (US) imaging probe using spatially resolved Doppler for diagnostic quality cardiovascular MR imaging (MRI) as an initial step toward hybrid US/MR fetal imaging. Methods: A newly developed technology for a dedicated MR-compatible phased array ultrasound-imaging probe acquired pulsed color Doppler carotid images, which were converted in near-real time to a trigger signal for cardiac cine and flow quantification MRI. Ultrasound and MR data acquired simultaneously were interference free. Conventional electrocardiogram (ECG) and the proposed spatially resolved Doppler triggering were compared in 10 healthy volunteers. A synthetic "false-triggered" image was retrospectively processed using metric optimized gating (MOG). Images were scored by expert readers, and sharpness, cardiac function and aortic flow were quantified. Four-dimensional (4-D) flow (two volunteers) showed feasibility of Doppler triggering over a long acquisition time. Results: Imaging modalities were compatible. US probe positioning was stable and comfortable.Image quality scores and quantified sharpness were statistically equal for Dopplerand ECG-triggering (p = 1.00). ECG-, Doppler-triggered, and MOG ejection fractions were equivalent (p= 1.00), with false-triggered values significantly lower (p 0.05). 4-D flow quantification gave consistent results between ECG and Doppler triggering. Conclusion: We report interference-free pulsed color Doppler ultrasound during MR data acquisition. Cardiovascular MRI of diagnostic quality was successfully obtained with pulsed color Doppler triggering. Significance: The hardware platform could further enable advanced free-breathing cardiac imaging. Doppler ultrasound triggering is applicable where ECG is compromised due to pathology or interference at higher magnetic fields, and where direct ECG is impossible, i.e., fetal imaging.
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.2017.2764111