Nanocatalysts‐Augmented and Photothermal‐Enhanced Tumor‐Specific Sequential Nanocatalytic Therapy in Both NIR‐I and NIR‐II Biowindows

The tumor microenvironment (TME) has been increasingly recognized as a crucial contributor to tumorigenesis. Based on the unique TME for achieving tumor‐specific therapy, here a novel concept of photothermal‐enhanced sequential nanocatalytic therapy in both NIR‐I and NIR‐II biowindows is proposed, w...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2019-02, Vol.31 (5), p.e1805919-n/a
Main Authors: Feng, Wei, Han, Xiuguo, Wang, Rongyan, Gao, Xiang, Hu, Ping, Yue, Wenwen, Chen, Yu, Shi, Jianlin
Format: Article
Language:English
Subjects:
Animals
Cancer
Catalysis
Cell death
Cell Line, Tumor
Cell Survival - drug effects
Cell Survival - radiation effects
Diagnostic systems
Disproportionation
Ferrosoferric Oxide - chemistry
Gluconic acid
Glucose
Glucose oxidase
Glucose Oxidase - chemistry
Glucose Oxidase - metabolism
Humans
Hydrogen peroxide
Hydrogen Peroxide - chemistry
Hydroxyl Radical - chemistry
Hydroxyl Radical - toxicity
Hydroxyl radicals
Hyperthermia, Induced
Infrared Rays
Iron oxides
Mice
nanocatalytic medicine
Nanoparticles - chemistry
Neoplasms - therapy
Oxidation
Phototherapy
Photothermal conversion
Polymers - chemistry
Polypyrroles
Pyrroles - chemistry
Side effects
synergistic therapy
theranostics
Therapy
Transplantation, Heterologous
tumor microenvironment
Tumors
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Summary:The tumor microenvironment (TME) has been increasingly recognized as a crucial contributor to tumorigenesis. Based on the unique TME for achieving tumor‐specific therapy, here a novel concept of photothermal‐enhanced sequential nanocatalytic therapy in both NIR‐I and NIR‐II biowindows is proposed, which innovatively changes the condition of nanocatalytic Fenton reaction for production of highly efficient hydroxyl radicals (•OH) and consequently suppressing the tumor growth. Evidence suggests that glucose plays a vital role in powering cancer progression. Encouraged by the oxidation of glucose to gluconic acid and H2O2 by glucose oxidase (GOD), an Fe3O4/GOD‐functionalized polypyrrole (PPy)‐based composite nanocatalyst is constructed to achieve diagnostic imaging‐guided, photothermal‐enhanced, and TME‐specific sequential nanocatalytic tumor therapy. The consumption of intratumoral glucose by GOD leads to the in situ elevation of the H2O2 level, and the integrated Fe3O4 component then catalyzes H2O2 into highly toxic •OH to efficiently induce cancer‐cell death. Importantly, the high photothermal‐conversion efficiency (66.4% in NIR‐II biowindow) of the PPy component elevates the local tumor temperature in both NIR‐I and NIR‐II biowindows to substaintially accelerate and improve the nanocatalytic disproportionation degree of H2O2 for enhancing the nanocatalytic‐therapeutic efficacy, which successfully achieves a remarkable synergistic anticancer outcome with minimal side effects. Based on the unique tumor microenvironment for achieving tumor‐specific therapy, a novel concept of photothermal‐enhanced sequential nanocatalytic therapy in both NIR‐I and NIR‐II biowindows is proposed, which innovatively changes the condition of the nanocatalytic Fenton reaction for highly efficient production of hydroxyl radicals and consequently suppressing the tumor growth.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201805919