The Study of Nerve Conduit with Biocompatibility and Electrical Stimulation Effect

Conductive polymers show great promise because of their electrical property based on bioelectricity in vivo. In order to search electro-activity materials which insure abduction of tissue, we synthesized conductive nerve conduits with poly-dl-lactic-acid (PDLLA) and tetra-aniline (TA). Preparation t...

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Bibliographic Details
Published in:Journal of Wuhan University of Technology. Materials science edition 2018-12, Vol.33 (6), p.1530-1539
Main Authors: Guo, Xinglei, Liu, Gang, He, Qundi, Xu, Haixing, Yu, Yunxuan, Ke, Changsheng, Ming, Xiaofei, Zhao, Meng, Wang, Xiaobin, Huang, Zhijun, Xu, Peihu
Format: Article
Language:English
Subjects:
Aniline
Biocompatibility
Bioelectricity
Chemistry and Materials Science
Electrical raceways
Electrical resistivity
Materials Science
Mechanical properties
Organic Materials
Reaction time
Rodents
Stimulation
Toxicity
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Summary:Conductive polymers show great promise because of their electrical property based on bioelectricity in vivo. In order to search electro-activity materials which insure abduction of tissue, we synthesized conductive nerve conduits with poly-dl-lactic-acid (PDLLA) and tetra-aniline (TA). Preparation technology of TA was optimized, and the properties of the conduit were studied. RSC96 cell were used to investigate the toxicity and electrical stimulation effect. SD rats were used to assess biocompatibility in vivo. The results showed that the reaction ratio of 1:1, the reaction time of 2 h and the HCl concentration of 2 mol/L were the optimum conditions for synthesis of TA. The influence of TA content on the mechanical properties, hydrophilicity, conductivity and microstructure of the nerve conduit was evaluated. Cell and histocompatibility study showed PDLLA/TA possessed good biocompatibility. These results showed it had application values in tissue projects.
ISSN:1000-2413
1993-0437
DOI:10.1007/s11595-018-2002-x