Photo-induced eradication of human colorectal adenocarcinoma HT-29 cells by carbon monoxide (CO) delivery from a Mn-based green luminescent photoCORM
The two photoCORMs [Mn(CO)3(phen)(Imdansyl)](CF3SO3) (2, right cuvette) and [Mn(CO)3(phen)(Pipdansyl)](CF3SO3) (3, left cuvette) display very different luminescence (λex = 405 nm) in MeCN solution due to different linkage between the dansyl fluorophore and the [Mn(CO)3] unit. [Display omitted] •A gr...
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Published in: | Inorganica Chimica Acta 2019-01, Vol.485, p.112-117 |
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Main Authors: | , , , |
Format: | Article |
Language: | eng |
Subjects: | |
Online Access: | Get full text |
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Summary: | The two photoCORMs [Mn(CO)3(phen)(Imdansyl)](CF3SO3) (2, right cuvette) and [Mn(CO)3(phen)(Pipdansyl)](CF3SO3) (3, left cuvette) display very different luminescence (λex = 405 nm) in MeCN solution due to different linkage between the dansyl fluorophore and the [Mn(CO)3] unit.
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•A green luminescent Mn-based photoCORM has been isolated and characterized.•This photoCORM releases 3 COs upon exposure to broadband visible light.•The photoreleased CO induces apoptotic death in human colorectal cancer cells.•This luminescent photoCORM can be tracked inside cellular targets.
Exogenous CO delivery to cellular targets for salutary purposes can be readily achieved with photoactive metal carbonyl complexes (photoCORMs). Mn(I)-based photoCORMs are often favored for their ability to release CO upon triggering with visible light (suitable for phototherapy of cancer). To date, the reported Mn(I)-based photoCORMs are all non-luminescent and hence the entry of these CO donors cannot be tracked within the targeted sites. A new luminescent Mn(I) photoCORM namely [Mn(CO)3(phen)(Pipdansyl)](CF3SO3) (3) has been reported. Synthetic strategy to isolate photoCORM 3 and its previous analogue [Mn(CO)3(phen)(Imdansyl)](CF3SO3) (2) has been highlighted to establish protocols for the future isolation of luminescent Mn(I)-based photoCORMs that could be employed as trackable photoCORMs for CO delivery. The entrance of 3 into human colorectal adenocarcinoma HT-29 cells has been visualized by confocal microscopic studies. Eradication of the cancer cells by CO delivery from 3 under visible light illumination has also been demonstrated. |
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ISSN: | 0020-1693 1873-3255 |